Date published: 2025-10-20

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1-Cyanoimidazole (CAS 36289-36-8)

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Alternate Names:
N-cyanoimidazole
Application:
1-Cyanoimidazole is a ligand and a pseudo-cyanide
CAS Number:
36289-36-8
Molecular Weight:
93.09
Molecular Formula:
C4H3N3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-Cyanoimidazole is an organic compound classified as a heterocyclic compound, featuring a distinctive five-membered ring containing both an imidazole group and a carbonitrile group. Renowned for its unique properties, 1-Cyanoimidazole finds widespread utility in the pharmaceutical and chemical industries. It serves as a fundamental building block in the synthesis of diverse drugs and acts as a intermediate in the production of various compounds. Moreover, owing to its capacity to interact with multiple biological targets, 1-Cyanoimidazole has found applications in scientific research. The versatility of 1-Cyanoimidazole is evident in its employment across numerous scientific research endeavors. It functions as a ligand for synthesizing metal complexes, acts as a precursor in peptide synthesis, and demonstrates inhibitory effects on enzymes. Furthermore, 1-Cyanoimidazole contributes to the synthesis of organic compounds like proteins, nucleic acids, and carbohydrates. Its involvement extends to investigating the structure and function of proteins and nucleic acids. By interacting with a diverse range of biological targets, including proteins, enzymes, and nucleic acids, 1-Cyanoimidazole exerts its influence. It forms covalent bonds with the active sites of enzymes, consequently impeding their catalytic activity and inhibiting their function. Additionally, through non-covalent bonding, it can interact with protein active sites, disrupting their normal functionality.


1-Cyanoimidazole (CAS 36289-36-8) References

  1. 1-Cyanoimidazole as a Mild and Efficient Electrophilic Cyanating Agent.  |  Wu, Yq., et al. 2000. Org Lett. 2: 795-797. PMID: 10814430
  2. Nitrenes, carbenes, diradicals, and ylides. Interconversions of reactive intermediates.  |  Wentrup, C. 2011. Acc Chem Res. 44: 393-404. PMID: 21452850
  3. Recent developments and applications of cyanamides in electrophilic cyanation.  |  Chaitanya, M. and Anbarasan, P. 2018. Org Biomol Chem. 16: 7084-7103. PMID: 30209455
  4. N-Cyanation of Primary and Secondary Amines with Cyanobenzio-doxolone (CBX) Reagent.  |  Chen, Z. and Yuan, W. 2021. Chemistry. 27: 14836-14840. PMID: 34390036
  5. Eco-friendly and regiospecific intramolecular cyclization reactions of cyano and carbonyl groups in N,N-disubstituted cyanamide.  |  Moustafa, AH., et al. 2022. Mol Divers. 26: 2813-2823. PMID: 35220547
  6. Chemical Ligation of Oligonucleotide Tags to Support Encoded Chemical Library Synthesis.  |  Litovchick, A. and Keefe, AD. 2022. Methods Mol Biol. 2541: 25-32. PMID: 36083539

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-Cyanoimidazole, 1 g

sc-206157
1 g
$372.00