1-Aminocyclopropane-1-carboxylic Acid CAS: 22059-21-8
MF: C4H7NO2
MW: 101.11
An agonist at the NMDA receptor glycine modulatory site.

1-Aminocyclopropane-1-carboxylic Acid (CAS 22059-21-8)

1-Aminocyclopropane-1-carboxylic Acid | CAS 22059-21-8 is rated 5.0 out of 5 by 2.
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Alternate Names: 1-Aminocyclopropanecarboxylic Acid; 1-Amino-1-carboxycyclopropane; 1-Aminocyclopropane-1-carboxylate
Application: 1-Aminocyclopropane-1-carboxylic Acid is an agonist at the NMDA receptor glycine modulatory site
CAS Number: 22059-21-8
Purity: ≥98%
Molecular Weight: 101.11
Molecular Formula: C4H7NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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1-Aminocyclopropane-1-carboxylic Acid is a small molecule agonist at the glycine modulatory site of the NMDA receptor. Described to mimic the effects of glycine at the NMDAR, 1-Aminocyclopropane-1-carboxylic Acid competitively inhibits binding of [3H]glycine and enhances the binding of [3H]MK-801 to NMDAR-coupled cation channels similarly to glycine (though with less efficacy). 1-Aminocyclopropane-1-carboxylic Acid is shown to block convulsions and death produced by NMDA exposure, significantly reducing seizure induction and cell death of NMDA-treated hippocampal neurons. 1-Aminocyclopropane-1-carboxylic Acid is produced endogenously in the tomato and other higher plants as a product of the action of 1-aminocyclopropane-1-carboxylic acid synthase in the biosynthesis of ethylene.


References

1. Adams, D.O., et al. 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 170-174. PMID: 16592605
2. Nadler, V., et al. 1988. Eur. J. Pharmacol. 157: 115-116. PMID: 2466672
3. Marvizón, J.C., et al. 1989. J. Neurochem. 52: 992-994. PMID: 2465385
4. Skolnick, P., et al. 1989. Life Sci. 45: 1647-1655. PMID: 2685487
5. Rottmann, W.H., et al. 1991. J. Mol. Biol. 222: 937-961. PMID: 1762159
6. Kolesnikov, Y.A., et al. 1994. Life Sci. 55: 1393-1398. PMID: 7934650
7. Zapata, A., et al. 1996. Neuroreport. 7: 397-400. PMID: 8730790
8. Viu, E., et al. 1998. J. Pharmacol. Exp. Ther. 285: 527-532. PMID: 9580593

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in DMSO, and water (40 mg/ml).
Storage :
Store at -20° C
Melting Point :
229-231° C (lit.)
Boiling Point :
~228.9° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
NMDA-induced release of arachidonic acid: IC50 = 131 µM (cerebellar granule cells); 3H-glycine: IC50 = 38 nM (rat forebrain membrane); Glutamate NMDA receptor: IC50 = 40 nM (Rattus norvegicus); Glutamate NMDA receptor: EC5050 = 140 nM (Rattus norvegicus)
pK Values :
pKa: 2.29, 2.73, pKb: 8.03
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GZ1110000
PubChem CID :
535
MDL Number :
MFCD00009944
EC Number :
217-162-5
Beilstein Registry :
2076413
SMILES :
C1CC1(C(=O)O)N

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Certificate of Analysis

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1-Aminocyclopropane-1-carboxylic Acid (CAS 22059-21-8)  Product Citations

See how others have used 1-Aminocyclopropane-1-carboxylic Acid (CAS 22059-21-8). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 34068420  Lorente, B.|Zugasti, I.|Sánchez-Blanco, MJ.|Nicolás, E.|Ortuño, MF.| et al. 2021. Plants (Basel). 10:

Citations 1 to 1 of 1 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-3508, is provided as a white to off-white crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-17
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Rated 5 out of 5 by from Excellent product I bought this product about a year ago and used it to determine bacterial ACC deaminase activity. I can say it is a quality product at a very cheap.
Date published: 2017-11-06
Rated 5 out of 5 by from Lizada Lizada, et al. (PubMed ID 543532) developed a simple and sensitive test for quantitation of 1-Aminocyclopropane-1-carboxylic Acid, also known as ACC. This method can detect ACC in amounts as small as 5pmoles. -SCBT Publication Review
Date published: 2015-02-19
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