1-Aminocyclopropane-1-carboxylic Acid CAS: 22059-21-8
MF: C4H7NO2
MW: 101.11
An agonist at the NMDA receptor glycine modulatory site.

1-Aminocyclopropane-1-carboxylic Acid (CAS 22059-21-8)

1-Aminocyclopropane-1-carboxylic Acid | CAS 22059-21-8 is rated 5.0 out of 5 by 2.
  • y_2020, m_11, d_30, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_202393, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 119ms
  • REVIEWS, PRODUCT
5
2
4
0
3
0
2
0
1
0
Alternate Names: 1-Aminocyclopropanecarboxylic Acid; 1-Amino-1-carboxycyclopropane; 1-Aminocyclopropane-1-carboxylate
Application: 1-Aminocyclopropane-1-carboxylic Acid is an agonist at the NMDA receptor glycine modulatory site
CAS Number: 22059-21-8
Purity: ≥98%
Molecular Weight: 101.11
Molecular Formula: C4H7NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

1-Aminocyclopropane-1-carboxylic Acid is a small molecule agonist at the glycine modulatory site of the NMDA receptor. Described to mimic the effects of glycine at the NMDAR, 1-Aminocyclopropane-1-carboxylic Acid competitively inhibits binding of [3H]glycine and enhances the binding of [3H]MK-801 to NMDAR-coupled cation channels similarly to glycine (though with less efficacy). 1-Aminocyclopropane-1-carboxylic Acid is shown to block convulsions and death produced by NMDA exposure, significantly reducing seizure induction and cell death of NMDA-treated hippocampal neurons. 1-Aminocyclopropane-1-carboxylic Acid is produced endogenously in the tomato and other higher plants as a product of the action of 1-aminocyclopropane-1-carboxylic acid synthase in the biosynthesis of ethylene.


References

1. Adams, D.O., et al. 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 170-174. PMID: 16592605
2. Nadler, V., et al. 1988. Eur. J. Pharmacol. 157: 115-116. PMID: 2466672
3. Marvizón, J.C., et al. 1989. J. Neurochem. 52: 992-994. PMID: 2465385
4. Skolnick, P., et al. 1989. Life Sci. 45: 1647-1655. PMID: 2685487
5. Rottmann, W.H., et al. 1991. J. Mol. Biol. 222: 937-961. PMID: 1762159
6. Kolesnikov, Y.A., et al. 1994. Life Sci. 55: 1393-1398. PMID: 7934650
7. Zapata, A., et al. 1996. Neuroreport. 7: 397-400. PMID: 8730790
8. Viu, E., et al. 1998. J. Pharmacol. Exp. Ther. 285: 527-532. PMID: 9580593

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in DMSO, and water (40 mg/ml).
Storage :
Store at -20° C
Melting Point :
229-231° C (lit.)
Boiling Point :
~228.9° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
NMDA-induced release of arachidonic acid: IC50 = 131 µM (cerebellar granule cells); 3H-glycine: IC50 = 38 nM (rat forebrain membrane); Glutamate NMDA receptor: IC50 = 40 nM (Rattus norvegicus); Glutamate NMDA receptor: EC5050 = 140 nM (Rattus norvegicus)
pK Values :
pKa: 2.29, 2.73, pKb: 8.03
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GZ1110000
PubChem CID :
535
MDL Number :
MFCD00009944
EC Number :
217-162-5
Beilstein Registry :
2076413
SMILES :
C1CC1(C(=O)O)N

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-3508, is provided as a white to off-white crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-17
  • y_2020, m_11, d_30, h_15CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.12
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_202393, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 157ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Excellent product I bought this product about a year ago and used it to determine bacterial ACC deaminase activity. I can say it is a quality product at a very cheap.
Date published: 2017-11-06
Rated 5 out of 5 by from Lizada Lizada, et al. (PubMed ID 543532) developed a simple and sensitive test for quantitation of 1-Aminocyclopropane-1-carboxylic Acid, also known as ACC. This method can detect ACC in amounts as small as 5pmoles. -SCBT Publication Review
Date published: 2015-02-19
  • y_2020, m_11, d_30, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_202393, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.