1-Aminocyclopropane-1-carboxylic Acid is a small molecule agonist at the glycine modulatory site of the NMDA receptor. Described to mimic the effects of glycine at the NMDAR, 1-Aminocyclopropane-1-carboxylic Acid competitively inhibits binding of [3H]glycine and enhances the binding of [3H]MK-801 to NMDAR-coupled cation channels similarly to glycine (though with less efficacy). 1-Aminocyclopropane-1-carboxylic Acid is shown to block convulsions and death produced by NMDA exposure, significantly reducing seizure induction and cell death of NMDA-treated hippocampal neurons. 1-Aminocyclopropane-1-carboxylic Acid is produced endogenously in the tomato and other higher plants as a product of the action of 1-aminocyclopropane-1-carboxylic acid synthase in the biosynthesis of ethylene.
1. Adams, D.O., et al. 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 170-174. PMID: 16592605 2. Nadler, V., et al. 1988. Eur. J. Pharmacol. 157: 115-116. PMID: 2466672 3. Marvizón, J.C., et al. 1989. J. Neurochem. 52: 992-994. PMID: 2465385 4. Skolnick, P., et al. 1989. Life Sci. 45: 1647-1655. PMID: 2685487 5. Rottmann, W.H., et al. 1991. J. Mol. Biol. 222: 937-961. PMID: 1762159 6. Kolesnikov, Y.A., et al. 1994. Life Sci. 55: 1393-1398. PMID: 7934650 7. Zapata, A., et al. 1996. Neuroreport. 7: 397-400. PMID: 8730790 8. Viu, E., et al. 1998. J. Pharmacol. Exp. Ther. 285: 527-532. PMID: 9580593
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What is the appearance of the compound?
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Excellent productI bought this product about a year ago and used it to determine bacterial ACC deaminase activity. I can say it is a quality product at a very cheap.
Date published: 2017-11-06
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LizadaLizada, et al. (PubMed ID 543532) developed a simple and sensitive test for quantitation of 1-Aminocyclopropane-1-carboxylic Acid, also known as ACC. This method can detect ACC in amounts as small as 5pmoles. -SCBT Publication Review
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