Date published: 2025-12-3

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1,4-Anhydroerythritol (CAS 4358-64-9)

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Alternate Names:
(3R,4S)-tetrahydrofuran-3,4-diol; Erythritan
Application:
1,4-Anhydroerythritol is a heterocyclic building block
CAS Number:
4358-64-9
Purity:
≥98%
Molecular Weight:
104.10
Molecular Formula:
C4H8O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,4-Anhydroerythritol is a compound that finds utility in the field of organic and analytical chemistry. It serves as a starting material in the synthesis of a variety of chemical targets due to the presence of reactive aldehyde groups formed by the removal of water (anhydro formation). Researchers utilize 1,4-Anhydroerythritol to explore reaction mechanisms and to synthesize complex molecules through reactions such as aldol condensation, reductive amination, and as a glycosidic bond-forming reagent. The compound is also of interest in carbohydrate chemistry, where it is used to study the properties and reactivities of sugar alcohols and their derivatives. Additionally, 1,4-Anhydroerythritol can be employed as a standard or reference compound in chromatographic methods for the quantification and analysis of polyols and their transformation products.


1,4-Anhydroerythritol (CAS 4358-64-9) References

  1. A combined X-ray and NMR study of borate esters of furanoidic cis-1,2-diols.  |  Benner, K. and Klüfers, P. 2000. Carbohydr Res. 327: 287-92. PMID: 10945677
  2. Selective hydrodeoxygenation of cyclic vicinal diols to cyclic alcohols over tungsten oxide-palladium catalysts.  |  Amada, Y., et al. 2014. ChemSusChem. 7: 2185-92. PMID: 24974957
  3. Hydrodeoxygenation of vicinal OH groups over heterogeneous rhenium catalyst promoted by palladium and ceria support.  |  Ota, N., et al. 2015. Angew Chem Int Ed Engl. 54: 1897-900. PMID: 25521866
  4. Nuclear magnetic resonance studies of the interactions between the organic germanium compound Ge-132 and saccharides.  |  Shimada, Y., et al. 2015. Carbohydr Res. 407: 10-5. PMID: 25699974
  5. Facile and rapid deprotection conditions for the cleavage of synthetic oligonucleotides from 1,4-anhydroerythritol-based universal polymer support.  |  Dhawan, G., et al. 2015. Nucleosides Nucleotides Nucleic Acids. 34: 149-62. PMID: 25710353
  6. Synthesis of 2-Butanol by Selective Hydrogenolysis of 1,4-Anhydroerythritol over Molybdenum Oxide-Modified Rhodium-Supported Silica.  |  Arai, T., et al. 2016. ChemSusChem. 9: 1680-8. PMID: 27226396
  7. Supported Molybdenum Catalysts for the Deoxydehydration of 1,4-Anhydroerythritol into 2,5-Dihydrofuran.  |  Sandbrink, L., et al. 2017. ChemSusChem. 10: 1375-1379. PMID: 28165202
  8. Preparation of Highly Active Monometallic Rhenium Catalysts for Selective Synthesis of 1,4-Butanediol from 1,4-Anhydroerythritol.  |  Wang, T., et al. 2019. ChemSusChem. 12: 3615-3626. PMID: 31134740
  9. Erythritol: Another C4 Platform Chemical in Biomass Refinery.  |  Nakagawa, Y., et al. 2020. ACS Omega. 5: 2520-2530. PMID: 32095676

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,4-Anhydroerythritol, 5 g

sc-223008
5 g
$300.00

1,4-Anhydroerythritol, 25 g

sc-223008A
25 g
$450.00