Date published: 2025-10-21

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1,2-O-Dihexadecyl-sn-glycerol (CAS 67337-03-5)

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Alternate Names:
(S)-2,3-Bis(hexadecyloxy)propan-1-ol
CAS Number:
67337-03-5
Molecular Weight:
540.94
Molecular Formula:
C35H72O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,2-O-Dihexadecyl-sn-glycerol finds application in the preparation of toll-like Receptor-2 Agonistic Diacylthioglycerol Lipopeptides. Additionally, it is utilized in synthesizing phospholipid analogs and evaluating their potential as phosphatidylinositol 4-kinase inhibitors. This synthetic lipid, 1,2-O-Dihexadecyl-sn-glycerol, serves as useful for studying membrane properties. It can be immobilized on a membrane surface or synthesized in solution and added to a monolayer for experimentation. Notably, 1,2-O-Dihexadecyl-sn-glycerol exhibits selectivity towards cholesterol and other neutral lipids in membranes. Furthermore, it demonstrates sensitivity to modifications such as quaternization and hydroxylation.


1,2-O-Dihexadecyl-sn-glycerol (CAS 67337-03-5) References

  1. A mixed ladderane/n-alkyl glycerol diether membrane lipid in an anaerobic ammonium-oxidizing bacterium.  |  Sinninghe Damsté, JS., et al. 2004. Chem Commun (Camb). 2590-1. PMID: 15543294
  2. Activation of protein kinase C by naturally occurring ether-linked diglycerides.  |  Ford, DA., et al. 1989. J Biol Chem. 264: 13818-24. PMID: 2760045
  3. A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination.  |  Taylor, MJ., et al. 2017. Cell. 169: 108-119.e20. PMID: 28340336

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,2-O-Dihexadecyl-sn-glycerol, 250 mg

sc-287223
250 mg
$180.00

1,2-O-Dihexadecyl-sn-glycerol, 1 g

sc-287223A
1 g
$195.00