Date published: 2026-5-1

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1-(2-Furoyl)piperazine (CAS 40172-95-0)

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Alternate Names:
2-Furoic piperazide
CAS Number:
40172-95-0
Molecular Weight:
180.20
Molecular Formula:
C9H12N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-(2-Furoyl)piperazine is an organic compound featuring a piperazine ring connected to a furoyl group. This white crystalline solid, soluble in ethanol and methanol, finds extensive use in scientific research, particularly in biochemical and physiological studies. Moreover, 1-(2-Furoyl)piperazine holds significance as a key synthetic intermediate for the production of pharmaceuticals and various other organic compounds. In the realm of scientific research, 1-(2-Furoyl)piperazine has played a pivotal role in investigating diverse subjects. Notably, it has been employed to examine the involvement of calcium-activated potassium channels in neuronal excitability, along with studying the impact of 1-(2-Furoyl)piperazine on the activity of enzymes associated with metabolic pathways. Moreover, researchers have utilized 1-(2-Furoyl)piperazine to explore the effects of drugs on the central nervous system. A significant action of 1-(2-Furoyl)piperazine involves acting as an agonist at calcium-activated potassium channels, which play a role in neuronal excitability. Additionally, this compound has demonstrated its ability to inhibit the activity of enzymes that participate in metabolic pathways like glycolysis and the tricarboxylic acid cycle.


1-(2-Furoyl)piperazine (CAS 40172-95-0) References

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  2. Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors.  |  Liu, W., et al. 2014. Bioorg Med Chem. 22: 292-302. PMID: 24316352
  3. 4-(Furan-2-carbon-yl)piperazin-1-ium 3,5-di-nitro-benzoate.  |  Kavitha, CN., et al. 2014. Acta Crystallogr Sect E Struct Rep Online. 70: o700-1. PMID: 24940274
  4. 2-Furoic piperazide derivatives as promising drug candidates of type 2 diabetes and Alzheimer's diseases: In vitro and in silico studies.  |  Abbasi, MA., et al. 2018. Comput Biol Chem. 77: 72-86. PMID: 30245349
  5. Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells.  |  Berdan, CA., et al. 2019. Cell Chem Biol. 26: 1027-1035.e22. PMID: 31080076
  6. Thienopyrimidine Derivatives as GPR55 Receptor Antagonists: Insight into Structure-Activity Relationship.  |  Figuerola-Asencio, L., et al. 2023. ACS Med Chem Lett. 14: 18-25. PMID: 36655130

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-(2-Furoyl)piperazine, 5 g

sc-222476
5 g
$25.00

1-(2-Furoyl)piperazine, 25 g

sc-222476A
25 g
$69.00