Date published: 2026-5-25

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1,2-Dioleoyloxy-3-(dimethylamino)propane (CAS 127512-29-2)

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Alternate Names:
DODAP
CAS Number:
127512-29-2
Molecular Weight:
648.05
Molecular Formula:
C41H77NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,2-Dioleoyloxy-3-(dimethylamino)propane, with the CAS number 127512-29-2, is a synthetic lipid molecule characterized by its structure which includes two oleoyl (oleic acid) chains and a dimethylamino propane group. This configuration makes the molecule amphiphilic, possessing both hydrophobic (due to the fatty acid chains) and hydrophilic (due to the dimethylamino group) properties, enabling it to interact uniquely with biological membranes. In research, this compound is primarily employed to study lipid bilayer assembly, membrane fluidity, and the dynamics of membrane-bound proteins, providing insights into membrane structure and function without the direct involvement in therapeutic contexts. Its unique structure allows for the formation of liposomes or micelles, crucial for studying drug delivery mechanisms and the encapsulation of various substances in a non-medical setup. Furthermore, the presence of the dimethylamino group offers a positive charge, which can be used to investigate interactions between charged molecules and the lipid environment, essential for understanding signaling pathways and membrane dynamics in cells. This chemical is particularly valuable in biophysical experiments designed to mimic or manipulate membrane properties, contributing significantly to our understanding of lipid-mediated cellular processes and membrane architecture in a purely scientific inquiry.


1,2-Dioleoyloxy-3-(dimethylamino)propane (CAS 127512-29-2) References

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  2. Development of a novel method for formulating stable siRNA-loaded lipid particles for in vivo use.  |  Wu, SY., et al. 2009. Pharm Res. 26: 512-22. PMID: 19023647
  3. Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles.  |  Leventis, R. and Silvius, JR. 1990. Biochim Biophys Acta. 1023: 124-32. PMID: 2317491
  4. Non-viral Vectors in Gene Therapy: Recent Development, Challenges, and Prospects.  |  Zu, H. and Gao, D. 2021. AAPS J. 23: 78. PMID: 34076797
  5. Lipid carriers for mRNA delivery.  |  Zhang, W., et al. 2023. Acta Pharm Sin B. 13: 4105-4126. PMID: 37799378
  6. Absence of Anaphylactic Reactions to Injection of Hemoglobin Vesicles (Artificial Red Cells) to Rodents.  |  Sakai, H., et al. 2024. ACS Omega. 9: 1904-1915. PMID: 38222647

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,2-Dioleoyloxy-3-(dimethylamino)propane, 100 mg

sc-208736
100 mg
$290.00