Molecular structure of VX-765, CAS Number: 273404-37-8
VX-765 (CAS 273404-37-8)
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Alternate Names:
N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide
CAS Number:
273404-37-8
Molecular Weight:
508.99
Molecular Formula:
C24H33ClN4O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
VX-765 is an inhibitor of caspase-1, a key enzyme involved in inflammation and apoptosis. It works by binding to the active site of the enzyme and preventing it from cleaving its substrates. This prevents the activation of downstream inflammatory pathways and apoptotic processes.
VX-765 (CAS 273404-37-8) References
- Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis. | McKenzie, BA., et al. 2018. Proc Natl Acad Sci U S A. 115: E6065-E6074. PMID: 29895691
- VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis. | Li, Y., et al. 2020. Exp Cell Res. 389: 111847. PMID: 31972218
- Effect of VX‑765 on the transcriptome profile of mice spinal cords with acute injury. | Chen, J., et al. 2020. Mol Med Rep. 22: 33-42. PMID: 32377730
- VX-765 enhances autophagy of human umbilical cord mesenchymal stem cells against stroke-induced apoptosis and inflammatory responses via AMPK/mTOR signaling pathway. | Sun, Z., et al. 2020. CNS Neurosci Ther. 26: 952-961. PMID: 32459063
- VX-765 reduces neuroinflammation after spinal cord injury in mice. | Chen, J., et al. 2021. Neural Regen Res. 16: 1836-1847. PMID: 33510091
- Inhibition of Caspase-1 Ameliorates Ischemia-Associated Blood-Brain Barrier Dysfunction and Integrity by Suppressing Pyroptosis Activation. | Liang, Y., et al. 2020. Front Cell Neurosci. 14: 540669. PMID: 33584203
- Airborne particulate matter (PM2.5) triggers ocular hypertension and glaucoma through pyroptosis. | Li, L., et al. 2021. Part Fibre Toxicol. 18: 10. PMID: 33663554
- VX-765 ameliorates inflammation and extracellular matrix accumulation by inhibiting the NOX1/ROS/NF-κB pathway in diabetic nephropathy. | Wang, X., et al. 2022. J Pharm Pharmacol. 74: 377-386. PMID: 34383065
- VX-765 ameliorates renal injury and fibrosis in diabetes by regulating caspase-1-mediated pyroptosis and inflammation. | Wen, S., et al. 2022. J Diabetes Investig. 13: 22-33. PMID: 34494385
- VX-765 prevents intestinal ischemia-reperfusion injury by inhibiting NLRP3 inflammasome. | Lyu, H., et al. 2022. Tissue Cell. 75: 101718. PMID: 35131633
- VX-765 has a Protective Effect on Mice with Ovarian Injury Caused by Chemotherapy. | Lee, P., et al. 2023. Curr Cancer Drug Targets. 23: 307-318. PMID: 36200259
- VX-765 Alleviates β-Amyloid Deposition and Secondary Degeneration in the Ipsilateral Hippocampus and Ameliorates Cognitive Decline after Focal Cortical Infarction in Rats. | Dong, D., et al. 2022. J Mol Neurosci. 72: 2389-2397. PMID: 36441377
- VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice. | Tao, H., et al. 2023. Ecotoxicol Environ Saf. 249: 114359. PMID: 36508797
- VX-765 ameliorates CKD VSMC calcification by regulating STAT3 activation. | Duan, Y., et al. 2023. Eur J Pharmacol. 945: 175610. PMID: 36858340
- VX-765 inhibits pyroptosis and reduces inflammation to prevent acute liver failure by upregulating PPARα expression. | Jiao, M., et al. 2023. Ann Hepatol. 28: 101082. PMID: 36893888
Inhibitor of:
AIM2, Antipain dihydrochloride, C9orf82, caspase-1, caspase-10, caspase-11, caspase-13, caspase-16, caspase-4, caspase-5, CDSN, CST, FBXW2, gasdermin, gasdermin A2, gasdermin A3, gasdermin C, granzyme F, ICE p20, ICE-LAP6, ICEBERG, ICH-1S, IFI-16, IL-1β, MACHβ1, NAIP1, NALP13, NALP14, NALP4B, NALP4f, NALP5, NALP7, NALP8, NALP9A, NALP9B, NIBP, p20-ARC, PERP (p53 apoptosis effector related to PMP22), and Pyhin1.Activator of:
IRF-2BP1, and LGP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VX-765, 5 mg | sc-475845 | 5 mg | $228.00 | |||
VX-765, 10 mg | sc-475845A | 10 mg | $302.00 | |||
VX-765, 50 mg | sc-475845B | 50 mg | $968.00 |