Unc18-2 Antibody (A-6): sc-390503

Unc18-2 Antibody (A-6) is a mouse monoclonal IgG1 antibody that detects Unc18-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Unc18-2 plays a crucial role in the regulation of exocytosis by acting as a chaperone molecule that binds to syntaxin, thereby preventing its interaction with cognate SNARE proteins. This interaction is vital for the proper functioning of synaptic transmission and hormone secretion, as Unc18-2 ensures that vesicles containing neurotransmitters or hormones are released at the right time and location. Unc18-2 localizes at the apical plasma membrane of intestinal, proximal tubule, and collecting duct epithelial cells, highlighting Unc18-2′s importance in cellular communication and transport processes. Additionally, Unc18-2 phosphorylation at specific sites can modulate activity and interactions, further emphasizing the significance of post-translational modifications in regulating protein function. With insights into the mechanisms of exocytosis and cellular signaling, anti-Unc18-2 antibody (A-6) serves as an essential tool for researchers studying these critical biological processes.

The preferred Unc18-2 antibody is Unc18-2 Antibody (B-2): sc-376639.