U-83836E CAS: 122003-11-6
MF: C30H44N6O2•2HCl
MW: 593.6
An agent that prevents hydrogen peroxide-induced F2 isoprostane production.

U-83836E (CAS 122003-11-6)

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Synonym: (-)2-((4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)methyl)-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol dihydrochloride
Application An agent that prevents hydrogen peroxide-induced F2 isoprostane production
CAS 등록번호: 122003-11-6
순도: 98%
분자량: 593.6
분자식: C30H44N6O22HCl
* 참조분석증명서대량의 측정 데이터(함수량포함).
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U-83836E prevents hydrogen peroxide-induced F2 isoprostane production in renal proximal tubular cells, prevents free radical mediated effects of oxyhemoglobin in vascular smooth muscle, and reduces secondary brain injury in a rabbit model of cryogenic trauma. Research shows that U-83836E improves survival of rat embryonic mesencephalic tissue stored at 4° C, and mitigates the toxicity of methanol on the antioxidant system of the rat brain. Western blot of cardiac tissue pretreated with U-83836E shows increase expression of HSP 70 (HSP72).


References

1. Vollrath, B., et al. 1995. Cardiovasc. Res. 30: 619-626. PMID: 8575010
2. Wilson, J.T., et al. 1995. J Trauma. 39: 473-477. PMID: 7473911
3. Salahudeen, A., et al. 1995. J. Am. Soc. Nephrol. 6: 1300-1303. PMID: 8589301
4. Grasbon-Frodl, E.M., et al. 1996. Brain Res. Bull. 39: 341-347. PMID: 9138743
5. Farbiszewski, R., et al. 2000. Toxicology. 156: 47-55. PMID: 11162875
6. Labruto, F., et al. 2006. Acad Emerg Med. 13: 7-12. PMID: 16365323
7. Sayyed, S.G., et al. 2006. Life Sci. 79: 777-783. PMID: 16581090

Physical State :
Solid
용해도 :
Soluble in water (30 mg/mL), and ethanol (>50 mg/mL).
저장 :
Store at -20° C
IC50 :
Iron-dependent lipid peroxidation: IC50 = 600 nM (rattus norvegicus)
pK Values :
pKa: 11.39, pKb: 12.04
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
107656
SMILES :
CC1=C(C(=C2CCC(OC2=C1C)(C)CN3CCN(CC3)C4=NC(=NC(=C4)N5CCCC5)N6CCCC6)C)O.Cl.Cl

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U-83836E  논문정보

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Citations 1 to 1 of {3} total

PMID: # 8589301  Salahudeen, A. et al. 1995. J. Am. Soc. Nephrol. 6: 1300-1303.

Citations 1 to 1 of {3} total
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