Tropicamide CAS: 1508-75-4
MF: C17H20N2O2
MW: 284.40
A mAChR M4 antagonist.

Tropicamide (CAS 1508-75-4)

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Alternate Names: N-Ethyl-2-phenyl-N-(4-pyridylmethyl hydracrylamide; Ro 1-7683
Application Tropicamide is a mAChR M4 antagonist
CAS 등록번호: 1508-75-4
순도: ≥99%
분자량: 284.40
분자식: C17H20N2O2
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Tropicamide is a mAChR M4 antagonist (ID50=214.20 nmoles) found on blood vessels and neuronal cells. The compound can weaken anti-inflammatory effects and is used in ocular studies.


References

1. Parkman, H.P., et al. 1999. Am. J. Physiol. 276: G1243-G1250. PMID: 10330016
2. Lazartigues, E., et al. 1999. Br. J. Pharmacol. 127: 1657-1665. PMID: 10455323
3. Hamasaki, I., et al. 2007. Jpn. J. Ophthalmol. 51: 111-115. PMID: 17401620
4. Tobin, G., et al. 2009. J. Physiol. Pharmacol. 60: 3-21. PMID: 19439804
5. Xiong, Y., et al. 2010. Eur. J. Pharmacol. 626: 290-296. PMID: 19836382

Physical State :
Solid
용해도 :
Soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (4.3 mg/ml), ethanol (57 mg/ml at 25° C), water (<1 mg/ml at 25° C), 0.1 M HCL(at 250 mg plus 5 mL, Clear to Slightly Hazy), and DMSO (57 mg/ml at 25° C).
저장 :
Store at 4° C
녹는점 :
98° C
비등점 :
~492.8° C at 760 mmHg (Predicted)
밀도 :
~1.2 g/cm3 (Predicted)
굴절률 :
n20D 1.59 (Predicted)
IC50 :
mAChR M4: IC50 = 25 nM (human); mAChR M5: IC50 = 89 nM (human); mAChR M2: IC50 = 105 nM (human); mAChR M3: IC50 = 142 nM (human); mAChR M1: IC50 = 281 nM (human)
Ki 데이타 :
mAChR M4: Ki= 3.48 nM (human); mAChR M3: Ki= 30 nM (human); mAChR M2: Ki= 37 nM (human); mAChR M5: Ki= 64 nM (human); mAChR M1: Ki= 68 nM (human)
pK Values :
pKb: 5.32 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
CY1487860
PubChem CID :
Merck Index :
14: 9780
MDL Number :
MFCD00058580
EC Number :
216-140-2
Beilstein Registry :
0285563
SMILES :
CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2

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PMID: # 25924704  Fei, F.|Li, J.|Rao, W.|Liu, W.|Chen, X.|Su, N.|Wang, Y.|Fei, Z.| et al. 2015. Cell Mol Neurobiol. 35: 1039-48.

PMID: # 19439804  Tobin, G. et al. 2009. J. Physiol. Pharmacol. 60: 3-21.

PMID: # 31175877  J. Allergy Clin. Immunol. 1058-1073.e3.

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