Date published: 2026-4-23

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Trimethylamine solution (ca. 25% in Isopropyl Alcohol, ca. 3mol/L) (CAS 75-50-3)

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Alternate Names:
Trimethylamine (ca. 25% in Isopropyl Alcohol, ca. 3mol/L); N,N-dimethylmethanamine
CAS Number:
75-50-3
Molecular Weight:
59.11
Molecular Formula:
C3H9N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Trimethylamine solution is a versatile compound notable for its role as a robust nucleophilic reagent in a myriad of chemical transformations. As a Lewis base, it effectively donates its lone pair of electrons, which are in the formation of new chemical bonds. This ability facilitates nucleophilic substitution reactions, a process in which trimethylamine solution targets specific electrophiles, leading to the displacement of a leaving group and subsequently creating diverse organic products. Beyond simple substitution reactions, trimethylamine solution is instrumental in the synthesis of quaternary ammonium salts. These salts are in various applications, particularly as phase-transfer catalysts which enhance the rate and efficiency of chemical reactions by facilitating the transfer of a reactant between two immiscible phases. The functional utility of trimethylamine in promoting the formation of carbon-nitrogen bonds is invaluable in organic synthesis, enabling chemists to construct complex organic molecules through sophisticated pathways.


Trimethylamine solution (ca. 25% in Isopropyl Alcohol, ca. 3mol/L) (CAS 75-50-3) References

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  2. Trimethylamine-The Extracorporeal Envoy.  |  Mitchell, SC. and Smith, RL. 2016. Chem Senses. 41: 275-9. PMID: 26809486
  3. The complex metabolism of trimethylamine in humans: endogenous and exogenous sources.  |  Chhibber-Goel, J., et al. 2016. Expert Rev Mol Med. 18: e8. PMID: 27126549
  4. Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease.  |  Fennema, D., et al. 2016. Drug Metab Dispos. 44: 1839-1850. PMID: 27190056
  5. Rapid Quantification of Trimethylamine.  |  Li, Z., et al. 2016. Anal Chem. 88: 5615-20. PMID: 27220015
  6. Microbial trimethylamine metabolism in marine environments.  |  Sun, J., et al. 2019. Environ Microbiol. 21: 513-520. PMID: 30370577
  7. Dietary lipids, gut microbiota and lipid metabolism.  |  Schoeler, M. and Caesar, R. 2019. Rev Endocr Metab Disord. 20: 461-472. PMID: 31707624
  8. Trimethylamine abatement in algal-bacterial photobioreactors.  |  Pascual, C., et al. 2020. Environ Sci Pollut Res Int. 27: 9028-9037. PMID: 31919828
  9. Trimethylamine modulates dauer formation, neurodegeneration, and lifespan through tyra-3/daf-11 signaling in Caenorhabditis elegans.  |  Khanna, A., et al. 2021. Aging Cell. 20: e13351. PMID: 33819374
  10. Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases.  |  He, S., et al. 2021. Cardiovasc Toxicol. 21: 593-604. PMID: 34003426
  11. Balancing the Equation: A Natural History of Trimethylamine and Trimethylamine-N-oxide.  |  Loo, RL., et al. 2022. J Proteome Res. 21: 560-589. PMID: 35142516
  12. The Role of a Gut Microbial-Derived Metabolite, Trimethylamine N-Oxide (TMAO), in Neurological Disorders.  |  Praveenraj, SS., et al. 2022. Mol Neurobiol. 59: 6684-6700. PMID: 35986843
  13. Clinical significance and potential role of trimethylamine N-oxide in neurological and neuropsychiatric disorders.  |  Mudimela, S., et al. 2022. Drug Discov Today. 27: 103334. PMID: 35998800
  14. The Role of the Gut Microbiome and Trimethylamine Oxide in Atherosclerosis and Age-Related Disease.  |  El Hage, R., et al. 2023. Int J Mol Sci. 24: PMID: 36768722
  15. Bacterial reduction of trimethylamine oxide.  |  Barrett, EL. and Kwan, HS. 1985. Annu Rev Microbiol. 39: 131-49. PMID: 3904597

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Trimethylamine solution (ca. 25% in Isopropyl Alcohol, ca. 3mol/L), 100 ml

sc-476596
100 ml
$63.00