Tomoxetine hydrochloride CAS: 82248-59-7
MF: C17H21NO•HCl
MW: 291.82
A selective SLC6A2 inhibitor.

Tomoxetine hydrochloride (CAS 82248-59-7)

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Application Tomoxetine hydrochloride is a selective SLC6A2 inhibitor
CAS 등록번호: 82248-59-7
순도: ≥99%
분자량: 291.82
분자식: C17H21NO•HCl
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* 참조분석증명서대량의 측정 데이터(함수량포함).

Tomoxetine hydrochloride (Atomoxetine, LY 139603) is a competitive and specific inhibitor of SLC6A2 while demonstrating weak ST and DAT inhibition as studied in synaptosomes of rat hypothalamus. Additionally, studies indicate that this (−) optical isomer is more effective than the (+) isomer, LY139602 (ent S-(+)-Atomoxetine Hydrochloride; sc-211408). In the prefrontal cortex of rats, Tomoxetine was reported to not cause an increase in dopamine within the striatum or nucleus accumbens which may be useful in additional research studies investigating the reward pathways of the brain. Tomoxetine hydrochloride is an inhibitor of NMDA.


References

1. Wong, D.T., et al. 1995. Life Sci. 57: 411-441. PMID: 7623609
2. Beck, S.G., et al. 1997. J. Pharmacol. Exp. Ther. 281: 115-122. PMID: 9103487
3. Owens, M.J., et al. 1997. J. Pharmacol. Exp. Ther. 283: 1305-1322. PMID: 9400006

Physical State :
Solid
용해도 :
Soluble to 50 mM in Water
저장 :
Store at room temperature
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
MDL Number :
MFCD06410992
SMILES :
Cl.CNCCC(OC1=C(C)C=CC=C1)C1=CC=CC=C1

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분석증명서

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