Tiliroside CAS: 20316-62-5
MF: C30H26O13
MW: 594.52
An antioxidant, antiproliferating, and free radical scavenger agent.

Tiliroside (CAS 20316-62-5)

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Application Tiliroside is an antioxidant, antiproliferating, and free radical scavenger agent
CAS 등록번호: 20316-62-5
순도: ≥97%
분자량: 594.52
분자식: C30H26O13
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* 참조분석증명서대량의 측정 데이터(함수량포함).
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Tiliroside, a flavanoid originally extracted from Magnoliafargesii, has been shown to have potent anti-complement activity on the classical pathway of the complement system. Additionally, this compound has been reported to have significant anti-proliferative effects. Furthermore, Tiliroside has been noted to strongly suppress serum GPT and GOT elevations in D-galactosamine (D-GaIN)/Lipopolysaccharide (sc-221854)(LPS)-induced liver injury in mice via inhibition of TNF-α production. Additionally, Tiliroside demonstrates antioxidant, anti-inflammatory, and scavenger properties through inhibition of enzymatic and non-enzymatic lipid peroxidation.


References

1. Jung, K.Y., et al. 1998. Biol. Pharm. Bull. 21: 1077-1078. PMID: 9821813
2. Dimas, K., et al. 1999. Leuk. Res. 23: 1021-1033. PMID: 10576507
3. Matsuda, H., et al. 2002. Bioorg. Med. Chem. 10: 707-712. PMID: 11814859
4. Sala, A., et al. 2003. Eur. J. Pharmacol. 461: 53-61. PMID: 12568916
5. Lee, S.Y., et al. 2005. Phytother Res. 19: 273-276. PMID: 16041765
6. Schinella, G.R., et al. 2007. Fitoterapia. 78: 1-6. PMID: 17084992

Physical State :
Solid
에서 유래된 :
Tilia sp.
용해도 :
Soluble in DMSO, and 100% ethanol.
저장 :
Store at -20° C
녹는점 :
269-271° C
비등점 :
943.89° C at 760 mmHg (Predicted)
밀도 :
1.69 g/cm3 (Predicted)
굴절률 :
n20D 1.76 (Predicted)
Optical Activity :
α20/D -57.0°±3.0°, c = 0.1 in methanol
IC50 :
HepG2: IC50 = 155 nM (human); CYP3A4: IC50 = 0.7 µM (human); Glyceraldehyde-3-phosphate dehydrogenase, glycosomal: IC50 = 46 µM (Trypanosoma cruzi); Xanthine Oxidase: IC50 = >100 µM (human); HIV1 RT: IC50 = 200 ug/ml (human)
pK Values :
pKa: 6.2 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00017454
SMILES :
C1=CC(=CC=C1C=CC(=O)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC=C(C=C5)O)O)O)O)O

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PMID: # 21623706  Moon, HI.|Jung, S.|Lee, YC.|Lee, JH.| et al. 2012. Immunopharmacol Immunotoxicol. 34: 113-5.

PMID: # 21520473  Chung, IM.|Song, HK.|Kim, SJ.|Moon, HI.| et al. 2011. Phytother Res. 25: 784-6.

PMID: # 20648692  Kim, SK.|Cho, SB.|Moon, HI.| et al. 2010. Phytother Res. 24: 1720-3.

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