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Thiomuscimol (CAS 62020-54-6)

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Alternate Names:
5-(Aminomethyl)-3(2H)-isothiazolone
Application:
Thiomuscimol is an analog used as a photoaffinity label for GABAA
CAS Number:
62020-54-6
Purity:
98%
Molecular Weight:
130.17
Molecular Formula:
C4H6N2OS
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Thiomuscimol, a structural analog of muscimol, may play a role in neuroscientific research, particularly through its application as a photoaffinity label for the study of GABA_A receptors. By binding to these receptors, Thiomuscimol effectively inhibits the attachment of [3H]muscimol, thereby providing critical insights into the binding sites and interaction dynamics within the receptor complexes. This specific interaction is for understanding the modulation of GABAergic neurotransmission in the brain. Thiomuscimol may be used for studying the mechanistic pathways and functional architectures of GABA_A receptors, thereby contributing to a deeper comprehension of synaptic functions and neuronal communication. This analog may be useful in the study of inhibitory neurotransmission and exploring the intricate network of neuronal signaling.


Thiomuscimol (CAS 62020-54-6) References

  1. Coupling between agonist and chloride ionophore sites of the GABA(A) receptor: agonist/antagonist efficacy of 4-PIOL.  |  Rabe, H., et al. 2000. Eur J Pharmacol. 409: 233-42. PMID: 11108817
  2. trans-4-Amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA(C) receptors.  |  Vien, J., et al. 2002. Br J Pharmacol. 135: 883-90. PMID: 11861315
  3. Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists.  |  Melikian, A., et al. 1992. J Med Chem. 35: 4092-7. PMID: 1331456
  4. Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.  |  Krehan, D., et al. 2006. J Med Chem. 49: 1388-96. PMID: 16480274
  5. Binding sites for [(3)H]GABA, [(3)H]flunitrazepam and [(35)S]TBPS in insect CNS.  |  Lummis, SC. and Sattelle, DB. 1986. Neurochem Int. 9: 287-93. PMID: 20493128
  6. Imidazole-4-acetic acid, a new lead structure for interaction with the taurine transporter in outer blood-retinal barrier cells.  |  Valembois, S., et al. 2017. Eur J Pharm Sci. 103: 77-84. PMID: 28259832
  7. Primary afferent terminal excitability in the normal and spastic mutant mouse spinal cord.  |  Yu, YB., et al. 1987. Eur J Pharmacol. 141: 371-82. PMID: 2889610
  8. Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas.  |  De Bessa, TC., et al. 2019. Cell Death Dis. 10: 143. PMID: 30760703
  9. Inhibition of GABA uptake in the rat hippocampal slice.  |  Korn, SJ. and Dingledine, R. 1986. Brain Res. 368: 247-55. PMID: 3697725
  10. Dihydromuscimol, thiomuscimol and related heterocyclic compounds as GABA analogues.  |  Krogsgaard-Larsen, P., et al. 1979. J Neurochem. 32: 1717-24. PMID: 448364
  11. The gamma-aminobutyric acid receptor in catfish brain.  |  Mathis, CA. and Tunnicliff, G. 1984. Comp Biochem Physiol C Comp Pharmacol Toxicol. 78: 479-81. PMID: 6149100
  12. The action of conformationally restricted analogues of GABA on Limulus and Helix central neurones.  |  James, VA., et al. 1978. Experientia. 34: 1630-1. PMID: 729738
  13. Thiomuscimol, a new photoaffinity label for the GABAA receptor.  |  Nielsen, M., et al. 1995. Eur J Pharmacol. 289: 109-12. PMID: 7781704
  14. Pentobarbital-like discriminative stimulus effects of direct GABA agonists in rats.  |  Grech, DM. and Balster, RL. 1993. Psychopharmacology (Berl). 110: 295-301. PMID: 7831422

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Thiomuscimol, 10 mg

sc-213035
10 mg
$458.00