Molecular structure of STA-21, CAS Number: 28882-53-3
STA-21 (CAS 28882-53-3)
See product citations (47)
Alternate Names:
(S)-Ochromycinone; Deoxytetrangomycin
Application:
STA-21 is a Stat3 transcription factor signaling inhibitor
CAS Number:
28882-53-3
Purity:
≥98%
Molecular Weight:
306.31
Molecular Formula:
C19H14O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
STA-21 is a small molecule inhibitor that is of interest in the field of biochemistry and cell biology research. It is known to inhibit the signal transducer and activator of transcription 3 (STAT3), which is a protein critically involved in cellular processes such as proliferation, survival, and differentiation. Researchers utilize STA-21 to study the STAT3 signaling pathway and its role in cellular communication. By inhibiting STAT3, STA-21 helps in dissecting the downstream effects of this pathway and in identifying the genes regulated by STAT3 transcriptional activity. It is also employed in studies aimed at understanding the molecular mechanisms that contribute to the aberrant activation of STAT3, which is observed in various cell signaling disorders.
STA-21 (CAS 28882-53-3) References
- A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. | Song, H., et al. 2005. Proc Natl Acad Sci U S A. 102: 4700-5. PMID: 15781862
- Design, synthesis, and studies of small molecule STAT3 inhibitors. | Bhasin, D., et al. 2008. Bioorg Med Chem Lett. 18: 391-5. PMID: 18006313
- LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model. | Fuh, B., et al. 2009. Br J Cancer. 100: 106-12. PMID: 19127268
- Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors. | Mankan, AK. and Greten, FR. 2011. Expert Opin Investig Drugs. 20: 1263-75. PMID: 21751940
- Combination of YM155, a survivin suppressant with a STAT3 inhibitor: a new strategy to treat diffuse large B-cell lymphoma. | Kaneko, N., et al. 2013. Leuk Res. 37: 1156-61. PMID: 23746965
- Everolimus-induced human keratinocytes toxicity is mediated by STAT3 inhibition. | Yamamoto, K., et al. 2013. J Exp Clin Cancer Res. 32: 83. PMID: 24423131
- STA-21, a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis. | Park, JS., et al. 2014. Arthritis Rheumatol. 66: 918-29. PMID: 24757144
- Tracking of STAT3 signaling for anticancer drug-discovery based on localized surface plasmon resonance. | Song, S., et al. 2016. Analyst. 141: 2493-501. PMID: 26998671
- STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis. | Ahmad, SF., et al. 2017. Immunobiology. 222: 206-217. PMID: 27717524
- Psoriatic inflammation enhances allergic airway inflammation through IL-23/STAT3 signaling in a murine model. | Nadeem, A., et al. 2017. Biochem Pharmacol. 124: 69-82. PMID: 27984001
- Combinatory treatment using tacrolimus and a STAT3 inhibitor regulate Treg cells and plasma cells. | Park, JS., et al. 2018. Int J Immunopathol Pharmacol. 32: 2058738418778724. PMID: 29873267
- Development of Oxadiazole-Based ODZ10117 as a Small-Molecule Inhibitor of STAT3 for Targeted Cancer Therapy. | Kim, BH., et al. 2019. J Clin Med. 8: PMID: 31684051
- IL-17 Induced Stromal Cell-Derived Factor-1 and Profibrotic Factor in Keloid-Derived Skin Fibroblasts via the STAT3 Pathway. | Lee, SY., et al. 2020. Inflammation. 43: 664-672. PMID: 31814061
- Combination of ERK2 and STAT3 Inhibitors Promotes Anticancer Effects on Acute Lymphoblastic Leukemia Cells. | Jasek-Gajda, E., et al. 2020. Cancer Genomics Proteomics. 17: 517-527. PMID: 32859630
- Targeting STAT3 prevents bile reflux-induced oncogenic molecular events linked to hypopharyngeal carcinogenesis. | Vageli, DP., et al. 2022. J Cell Mol Med. 26: 75-87. PMID: 34850540
Inhibitor of:
IFIT3, IL-23, Stat3, and Transcription Factor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
STA-21, 1 mg | sc-200757 | 1 mg | $298.00 |