Molecular structure of SRT1720, CAS Number: 1001645-58-4
SRT1720 (CAS 1001645-58-4)
See product citations (13)
Alternate Names:
SRT 1720 Hydrochloride; N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide hydrochloride
Application:
SRT1720 is a selective SIRT1 activator
CAS Number:
1001645-58-4
Purity:
≥98%
Molecular Weight:
506.02
Molecular Formula:
C25H23N7OS•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SRT1720 is a NAD-dependent deacetylase sirtuin-1 (SIRT1) activator (EC50 = 0.16 μM) highly selective for SIRT1 over SIRT2 or SIRT3. It binds to the SIRT1 enzyme-peptide substrate complex at an allosteric site amino-terminal to the catalytic domain and lower the Michaelis constant for acetylated substrates. Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and may act to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Studies in yeast suggest that sirtuins may be involved in epigentic gene silencing and deactylation of proteins that regulate the cell cycle. It can extend lifespan in yeast and C. elegans in a manner that resembles caloric restriction.
SRT1720 (CAS 1001645-58-4) References
- Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. | Milne, JC., et al. 2007. Nature. 450: 712-6. PMID: 18046409
- Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells. | Chauhan, D., et al. 2011. Br J Haematol. 155: 588-98. PMID: 21950728
- SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice. | Suzuki, K., et al. 2012. Oncol Rep. 27: 1726-32. PMID: 22470132
- Sirtuin activators and inhibitors. | Villalba, JM. and Alcaín, FJ. 2012. Biofactors. 38: 349-59. PMID: 22730114
- The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury. | Fan, H., et al. 2013. Kidney Int. 83: 404-13. PMID: 23302720
- Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism. | Nguyen, GT., et al. 2013. Acta Crystallogr D Biol Crystallogr. 69: 1423-32. PMID: 23897466
- SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway. | Cao, L., et al. 2013. Braz J Med Biol Res. 46: 659-69. PMID: 24036938
- The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet. | Mitchell, SJ., et al. 2014. Cell Rep. 6: 836-43. PMID: 24582957
- SRT1720 induces lysosomal-dependent cell death of breast cancer cells. | Lahusen, TJ. and Deng, CX. 2015. Mol Cancer Ther. 14: 183-92. PMID: 25411356
- SRT1720 Pretreatment Promotes Mitochondrial Biogenesis of Aged Human Mesenchymal Stem Cells and Improves Their Engraftment in Postinfarct Nonhuman Primate Hearts. | Zeng, Z., et al. 2021. Stem Cells Dev. 30: 386-398. PMID: 33567991
- SRT1720 enhances maturity and quality of oocytes in aged mice. | Liu, MJ., et al. 2021. Anim Sci J. 92: e13608. PMID: 34405491
- SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis. | Tan, P., et al. 2021. Oncogene. 40: 6081-6092. PMID: 34471236
- Shear stress-induced cellular senescence blunts liver regeneration through Notch-sirtuin 1-P21/P16 axis. | Duan, JL., et al. 2022. Hepatology. 75: 584-599. PMID: 34687050
- SRT1720 induces SIRT1-independent cell death in adult T-cell leukemia/lymphoma. | Kozako, T., et al. 2022. FEBS J. 289: 3477-3488. PMID: 35029032
Inhibitor of:
Angptl5, BNIP-2, Heat shock protein family A (Hsp70), KLHL6, MondoA, MYBBP1A, PGC-1α, SIRT1, SUMO-2, SUT-1, and TUSC5.Activator of:
1190007I07Rik, 2310042D19Rik, 3830417A13Rik, 4933412E24Rik, ABCG8, ABHD5, ACAD-9, ACSL6, ACSM2B, AdipoR1, AMPKγ1, ANT1, APHC, apoA-V, ARGLU1, ATAD1, ATP11, BFZB, BMAL2, BRCC2, BRMS1L, BRP44L, C17orf63, CHCHD2, CHCHD3, CLS1, CLYBL, COQ4, CoREST, COX4, DBT, DGUOK, EF-1δ, EG668114, FADS6, FASTKD2, FOXK1, FOXRED1, FUNDC2, FVT1, GABP-β2, Gm749, GRB10, Grim19, GS2, GTPBP3, GUF1, HARS2, HIBCH, LASS3, LIPI, LSDP5, LYRM1, MAF1, MFSD6L, MIER2, MINOS1, MRP-L15, MRP-L36, MRP-L45, MRP-L46, MRP-L52, MTMR6, MTP18, MUL1, NDUFA7, NDUFB5, NDUFS2, NDUFS3, NF-YB, nm23-H4, NNT, p53AIP1, PARP-12, PDSS2, PRELI, RARS2, Rev-erbβ, S19BP, SART-1, SCAF1, SDSL, SH3TC1, Sir2, SIRT1, SLC25A35, Spartin, SPT6, ST2, TFB1M, TIGAR, Tim23B, TMEM135, Tom40B, TTC39C, tuberin, USP1, USP30, YME1L1, ZBRK1, and ZNF281.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SRT1720, 5 mg | sc-364624 | 5 mg | $197.00 | |||
SRT1720, 10 mg | sc-364624A | 10 mg | $364.00 |