SR 95531 Hydrobromide CAS: 104104-50-9
MF: C15H17N3O3•HBr
MW: 368.23
A selective GABAA receptor antagonist.

SR 95531 Hydrobromide (CAS 104104-50-9)

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SR 95531 Hydrobromide is rated 5.0 out of 5 by 1.
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Alternate Names: Gabazine; 6-imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid, monohydrobromide
Application SR 95531 Hydrobromide is a selective GABAA receptor antagonist
CAS 등록번호: 104104-50-9
순도: ≥98%
분자량: 368.23
분자식: C15H17N3O3•HBr
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

SR 95531 Hydrobromide is a selective GABAA receptor antagonist. This compound displaces [3H]-GABA with a Ki of 150 nM. SR 95531 Hydrobromide selectively antagonizes GABA-induced Cl- currents with little action on pentobarbitone-induced currents. SR 95531 Hydrobromide acts as a low affinity GlyR(glycine receptor)antagonist.


References

1. Heaulme, M. et al. 1986. Brain Res. 384(2): 224-231. PMID: 3022866
2. Uchida, I. et al. 1996. Eur. J. Pharmacol. 307(1): 89-96. PMID: 8831109
3. Beato, M. et al. 2007. J. Physiol. (Lond.). 580(Pt 1): 171-179. PMID: 17218350
4. Blazquez, P.M. and Yakusheva, T.A. 2015. Cell Rep. 11(7): 1043-1053. PMID: 25959822

Physical State :
Solid
용해도 :
Soluble in water (>10 mg/ml), DMSO (100 mM), ethanol (20 mM), and phosphate buffered saline (5 mM).
저장 :
Store at 4° C
굴절률 :
n20D ~1.60 (Predicted)
IC50 :
Mus musculus: IC50 = 240 nM; Peak currents in cerebral cortical neurones: IC50 = 240 nM (rat); GABA-B receptor 1: IC50 = >10 µM (rat)
Ki 데이타 :
GABA-A receptor; anion channel: Ki= 70 nM (rat)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00055135
SMILES :
COC1=CC=C(C=C1)C2=NN(C(=N)C=C2)CCCC(=O)O.Br

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