SPHK 1 Inhibitor 5C CAS: 120005-55-2
MF: C26H45NO4
MW: 435.64
A selective inhibitor of SphK1.

SPHK 1 Inhibitor 5C (CAS 120005-55-2)

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Alternate Names: SKI 5C; CAY10621
Application SPHK 1 Inhibitor 5C is a selective inhibitor of SphK1
CAS 등록번호: 120005-55-2
순도: ≥98%
분자량: 435.64
분자식: C26H45NO4
추가 정보: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).
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SPHK 1 Inhibitor 5C is a selective inhibitor of SphK1, both in vitro (IC50 = 3.3 μM) and in U937 cells overexpressing human SphK1 (70% inhibition at 5 μM). The sphingosine kinases (SphK) phosphorylate sphingosine, producing the important lipid mediator sphingosine-1-phosphate (S1P). The two known kinases, SphK1 and SphK2, have different developmental and tissue expression patterns, suggesting that they have distinct physiological functions. Notably, SphK1 is overexpressed in several forms of cancer and inhibition of SphK1 inhibits tumor growth. It has no inhibitory effect on SphK2 either in vitro or in cells. Similarly, this chemical does not reduce the activity of protein kinase C (PKC) except at very high concentration (>75 μM).


References

1. Spiegel, S. and Milstien, S. 2007. J. Biol. Chem. 282: 2125-2129. PMID: 17135245
2. Takabe, K., et al. 2008. Pharmacol. Rev. 60: 181-195. PMID: 18552276
3. Shida, D., et al. 2008. Curr Drug Targets. 9: 662-673. PMID: 18691013
4. Wong, L., et al. 2009. J. Med. Chem. 52: 3618-3626. PMID: 19469544

Formulation :
A solution in methyl acetate
Physical State :
Liquid
용해도 :
Soluble in ethanol (~2 mg/ml), DMSO (~2 mg/ml), and DMF (~2 mg/ml).
저장 :
Store at -20° C
비등점 :
57° C
굴절률 :
n20D 1.48 (Predicted)
IC50 :
SphK1: IC50 = 3.3 µM (human)
Ki 데이타 :
SphK1: Ki= 3 µM (human)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
Transport :
UN 1231, Class 3, Packing group II
PubChem CID :
MDL Number :
MFCD18428021
SMILES :
CCCCCCCCCCCCCC#CC(=O)[[email protected]@H]1COC(N1C(=O)OC(C)(C)C)(C)C

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SPHK 1 Inhibitor 5C (CAS 120005-55-2)  논문정보

다른 사용자의 SPHK 1 Inhibitor 5C (CAS 120005-55-2)사용법보기. 클릭하여 PubMed entry보기 .

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PMID: # 33761358  Wurster, S.|Ruiz, OE.|Samms, KM.|Tatara, AM.|Albert, ND.|Kahan, PH.|Nguyen, AT.|Mikos, AG.|Kontoyiannis, DP.|Eisenhoffer, GT.| et al. 2021. Cell Rep. 34: 108896.

PMID: # 29805524  Zhao, Z.|Ma, J.|Hu, B.|Zhang, Y.|Wang, S.| et al. 2018. Exp Ther Med. 15: 5007-5016.

PMID: # 30317247  Wang, S.|Zhang, Q.|Wang, Y.|You, B.|Meng, Q.|Zhang, S.|Li, X.|Ge, Z.| et al. 2018. Med Sci Monit. 24: 7322-7328.

PMID: # 30575912  Eur Rev Med Pharmacol Sci. 8722-8730.

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