Spastin Antibody (Sp 6C6): sc-81624
- Spastin Antibody (Sp 6C6) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 200 µg/ml
- raised against recombinant Spastin of human origin
- recommended for detection of Spastin of mouse, rat and human origin by WB, IP and IF
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Spastin Antibody (Sp 6C6) for WB applications. These reagents are now offered in bundles with Spastin Antibody (Sp 6C6) (see ordering information below).
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Spastin Antibody (Sp 6C6) is a mouse monoclonal IgG2a antibody that detects Spastin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Spastin is a crucial member of the AAA protein family, characterized by its ATPase domain, and plays a significant role in various cellular processes, including intracellular motility, membrane trafficking, and organelle biogenesis. This 616 amino acid protein is predominantly localized in the nucleus and cytoplasm, where anti-Spastin antibody (Sp 6C6) reveals essential functions in microtubule dynamics, influencing the assembly and function of nuclear protein complexes. The importance of Spastin is underscored by its association with hereditary spastic paraplegia (HSP), particularly the most common form, spastic paraplegia 4, which arises from mutations in the SPAST gene. These mutations account for approximately 40% of all autosomal dominant HSP cases, leading to spastic lower extremity weakness due to retrograde axonopathy of corticospinal motor neurons. Spastin (Sp 6C6) antibody serves as an invaluable tool for researchers studying the molecular mechanisms underlying these neurological disorders and the broader implications of microtubule dynamics in cellular function.
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Spastin Antibody (Sp 6C6) References:
- Spastin and microtubules: Functions in health and disease. | Salinas, S., et al. 2007. J Neurosci Res. 85: 2778-82. PMID: 17348041
- The AAA ATPase spastin links microtubule severing to membrane modelling. | Lumb, JH., et al. 2012. Biochim Biophys Acta. 1823: 192-7. PMID: 21888932
- Spastin Interacts with CRMP5 to Promote Neurite Outgrowth by Controlling the Microtubule Dynamics. | Ji, Z., et al. 2018. Dev Neurobiol. 78: 1191-1205. PMID: 30257070
- Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation. | Sardina, F., et al. 2020. Life Sci Alliance. 3: PMID: 33106322
- Spastin interacts with CRMP5 to promote spindle organization in mouse oocytes by severing microtubules. | Jin, Z., et al. 2022. Zygote. 30: 80-91. PMID: 34034836
- Rab3A interacts with spastin to regulate neurite outgrowth in hippocampal neurons. | Yang, Y., et al. 2023. Biochem Biophys Res Commun. 643: 77-87. PMID: 36587525
- Inhibition of spastin impairs motor function recovery after spinal cord injury. | Yang, J., et al. 2023. Brain Res Bull. 205: 110806. PMID: 37918696
- Spastin regulates anaphase chromosome separation distance and microtubule-containing nuclear tunnels. | Kelley, ME., et al. 2024. Mol Biol Cell. 35: ar48. PMID: 38335450
- Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery. | Aiken, J. and Holzbaur, ELF. 2024. Curr Biol. 34: 1687-1704.e8. PMID: 38554708
- Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis. | Raby, A., et al. 2024. iScience. 27: 110683. PMID: 39252960
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Spastin Antibody (Sp 6C6) | sc-81624 | 200 µg/ml | $322.00 | |||
Spastin Antibody (Sp 6C6): m-IgG Fc BP-HRP Bundle | sc-537251 | 200 µg Ab; 10 µg BP | $361.00 | |||
Spastin Antibody (Sp 6C6): m-IgGκ BP-HRP Bundle | sc-534476 | 200 µg Ab; 40 µg BP | $361.00 | |||
Spastin Antibody (Sp 6C6): m-IgG2a BP-HRP Bundle | sc-547948 | 200 µg Ab; 10 µg BP | $361.00 |