Sall4 Antibody (F-2): sc-377432
- Sall4 Antibody (F-2) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 671-890 mapping within an internal region of Sall4 of mouse origin
- recommended for detection of Sall4 of mouse origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-377432 X, 200 µg/0.1 ml)
- m-IgG2a BP-HRP is the preferred secondary detection reagent for Sall4 Antibody (F-2) for WB applications. This reagent is now offered in a bundle with Sall4 Antibody (F-2) (see ordering information below).
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Sall4 Antibody (F-2) is a mouse monoclonal IgG2a light chain antibody that detects Sall4 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sall4 is a crucial transcription factor that plays a significant role in early embryonic development, particularly in the regulation of pluripotency and differentiation of stem cells. Expression of Sall4 is vital for the proper formation of various structures during embryogenesis, including the head region and primitive streak, which are essential for establishing the body plan of the developing organism. Sall4′s ability to interact with other transcription factors and regulatory proteins underscores its importance in maintaining the balance between self-renewal and differentiation in stem cells. Furthermore, aberrations in Sall4 expression have been linked to developmental disorders and certain cancers, highlighting Sall4′s potential as a biomarker for disease and a target for therapeutic intervention. Anti-Sall4 antibody (F-2) provides a reliable tool for researchers investigating the role of Sall4 in developmental biology and disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Sall4 Antibody (F-2) References:
- The role of stem cell factor SALL4 in leukemogenesis. | Gao, C., et al. 2011. Crit Rev Oncog. 16: 117-27. PMID: 22150312
- Clinicopathologic characteristics of SALL4-immunopositive hepatocellular carcinoma. | Shibahara, J., et al. 2014. Springerplus. 3: 721. PMID: 26034695
- Functional and clinical significance of SALL4 in breast cancer. | Dirican, E. and Akkiprik, M. 2016. Tumour Biol. 37: 11701-11709. PMID: 27444278
- SALL4 activates TGF-β/SMAD signaling pathway to induce EMT and promote gastric cancer metastasis. | Zhang, X., et al. 2018. Cancer Manag Res. 10: 4459-4470. PMID: 30349378
- SALL4 promotes tumor progression in breast cancer by targeting EMT. | Chen, T., et al. 2020. Mol Carcinog. 59: 1209-1226. PMID: 32835442
- Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy. | Yang, J., et al. 2021. Cancer Res. 81: 6018-6028. PMID: 34593523
- SALL4-related gene signature defines a specific stromal subset of pancreatic ductal adenocarcinoma with poor prognostic features. | Vienot, A., et al. 2023. Mol Oncol. 17: 1356-1378. PMID: 36587397
- Structure of SALL4 zinc finger domain reveals link between AT-rich DNA binding and Okihiro syndrome. | Watson, JA., et al. 2023. Life Sci Alliance. 6: PMID: 36635047
- Sall4 restricts glycolytic metabolism in limb buds through transcriptional regulation of glycolytic enzyme genes. | Kawakami, H., et al. 2023. Dev Biol. 501: 28-38. PMID: 37301463
- Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. | Ma, X., et al. 2023. Sci Rep. 13: 22088. PMID: 38086859
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sall4 Antibody (F-2) | sc-377432 | 200 µg/ml | $322.00 | |||
Sall4 Antibody (F-2): m-IgG2a BP-HRP Bundle | sc-546066 | 200 µg Ab; 10 µg BP | $361.00 | |||
Sall4 Antibody (F-2) X | sc-377432 X | 200 µg/0.1 ml | $322.00 |