(S)-10-Hydroxycamptothecin CAS: 19685-09-7
MF: C20H16N2O5
MW: 364.35
A camptothecin derivative that inhibits DNA topoisomerase I.

(S)-10-Hydroxycamptothecin (CAS 19685-09-7)

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Alternate Names: (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Hydroxycamptothecin
Application (S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase I
CAS 등록번호: 19685-09-7
순도: ≥98%
분자량: 364.35
분자식: C20H16N2O5
추가 정보: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

(S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase by enacting strand breaks in chromosomal DNA and inducing apoptosis. (S)-10-Hydroxycamptothecin is an inhibitor of Topo I.


References

1. Hertzberg, R.P., et al. 1989. Biochemistry. 28: 4629-4638. PMID: 2548584
2. Cotter, T.G., et al. 1992. Anticancer Res. 12: 773-779. PMID: 1622137

Physical State :
Solid
용해도 :
Soluble in DMSO (5 mg/ml), DMF, and methanol.
저장 :
Store at -20° C
녹는점 :
268-270° C
비등점 :
820.71° C at 760 mmHg (Predicted)
밀도 :
1.61 g/cm3 (Predicted)
굴절률 :
n20D 1.78 (Predicted)
IC50 :
A2780: IC50 = 4 nM (human); HepG2: IC50 = 5.4 nM (human); MDA-231: IC50 = 7.27 nM; HT-29: IC50 = 8.8 nM (human); BT-20: IC50 = 34.3 nM
pK Values :
pKa: 8.93 (Predicted), pKb: 4.97 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
RTECS :
UQ0491700
PubChem CID :
MDL Number :
MFCD00189425
SMILES :
CC[[email protected]@]1(O)C(=O)OCC2=C1C=C1N(CC3=CC4=C(C=CC(O)=C4)N=C13)C2=O

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