Rtn-1C Antibody (4A71): sc-71982
- Rtn-1C Antibody (4A71) is a mouse monoclonal IgG1 κ Rtn-1C antibody, cited in 2 publications, provided at 200 µg/ml
- raised against synthetic peptide encompassing the unique 20 N-terminal amino acid sequence of Reticulon-1C
- recommended for detection of Rtn-1C of mouse, rat and human origin by WB, IP, IF and IHC(P)
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Rtn-1C Antibody (4A71) for WB and IHC(P) applications. These reagents are now offered in bundles with Rtn-1C Antibody (4A71) (see ordering information below).
Rtn-1C Antibody (4A71) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rtn-1C protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Rtn-1C antibody (4A71) is available as a non-conjugated format. The Reticulon (Rtn) family, which includes Rtn-1, Rtn-2, Rtn-3, and Nogo, plays a crucial role in the structure and function of the endoplasmic reticulum (ER). Rtn-1C anchors to the ER membrane through its C-terminal region, which is essential for maintaining ER integrity and facilitating proper protein folding and trafficking. Rtn-1C is predominantly expressed in neural and neuroendocrine tissues, where Rtn-1C contributes to neuroendocrine secretion and membrane dynamics. Notably, Rtn-1C expression strongly associates with neuronal differentiation, making Rtn-1C a valuable marker in studies of neurodevelopment and neurodegenerative diseases. Additionally, the gene encoding Rtn-1 is located on human chromosome 14q23.1 and expresses as three isoforms—Rtn-1A, Rtn-1B, and Rtn-1C—through alternative splicing, highlighting the complexity and functional diversity of the Reticulon family in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rtn-1C Antibody (4A71) References:
- Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13. | Moreira, EF., et al. 1999. Genomics. 58: 73-81. PMID: 10331947
- Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. | GrandPré, T., et al. 2000. Nature. 403: 439-44. PMID: 10667797
- Subcellular localization and supramolecular organization of neuroendocrine-specific protein B (NSP-B) in small cell lung cancer. | Senden, NH., et al. 1994. Eur J Cell Biol. 65: 341-53. PMID: 7720728
- NSP-encoded reticulons are neuroendocrine markers of a novel category in human lung cancer diagnosis. | van de Velde, HJ., et al. 1994. Cancer Res. 54: 4769-76. PMID: 8062278
- Molecular cloning of a novel mouse gene with predominant muscle and neural expression. | Geisler, JG., et al. 1998. Mamm Genome. 9: 274-82. PMID: 9530622
- Neuronal differentiation is accompanied by NSP-C expression. | Hens, J., et al. 1998. Cell Tissue Res. 292: 229-37. PMID: 9560466
- cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons. | Roebroek, AJ., et al. 1998. Genomics. 51: 98-106. PMID: 9693037
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rtn-1C Antibody (4A71) | sc-71982 | 200 µg/ml | $322.00 | |||
Rtn-1C Antibody (4A71): m-IgG Fc BP-HRP Bundle | sc-539436 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rtn-1C Antibody (4A71): m-IgG1 BP-HRP Bundle | sc-541485 | 200 µg Ab; 20 µg BP | $361.00 |