Reptin 52 Antibody (D-6): sc-374363
- Reptin 52 Antibody (D-6) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 134-295 mapping within an internal region of Reptin 52 of human origin
- recommended for detection of Reptin 52 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- TransCruz reagent for ChIP application (sc-374363 X, 200 µg/0.1 ml)
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Reptin 52 Antibody (D-6) for WB applications. This reagent is now offered in a bundle with Reptin 52 Antibody (D-6) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
QUICK LINKS
Reptin 52 Antibody (D-6) is a mouse monoclonal IgG1 antibody that detects Reptin 52 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Reptin 52, also known as RUVBL2, is a crucial member of the ATPase/helicase family and plays a significant role in various cellular processes, including transcriptional regulation and chromatin remodeling. Reptin 52 is primarily located in the nucleus, where RUVBL2 is involved in the assembly of transcriptional complexes and the modulation of gene expression. Nuclear localization of Reptin 52 is vital for function, as RUVBL2 interacts with key transcription factors, such as Myc and Pontin 52, facilitating roles in oncogenic transformation and cellular proliferation. Notably, Reptin 52′s interaction with Myc is essential for oncogenic activity of Myc, highlighting importance in cancer biology. Formation of complexes with other proteins by Reptin 52 underscores RUVBL2′s role as a critical regulator in various signaling pathways, making Reptin 52 a valuable target for research in cancer and other diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Reptin 52 Antibody (D-6) References:
- Cloning, expression, purification, crystallization and preliminary X-ray analysis of the human RuvBL1-RuvBL2 complex. | Gorynia, S., et al. 2008. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64: 840-6. PMID: 18765919
- Structural and functional insights into a dodecameric molecular machine - the RuvBL1/RuvBL2 complex. | Gorynia, S., et al. 2011. J Struct Biol. 176: 279-91. PMID: 21933716
- Conformational transitions regulate the exposure of a DNA-binding domain in the RuvBL1-RuvBL2 complex. | López-Perrote, A., et al. 2012. Nucleic Acids Res. 40: 11086-99. PMID: 23002137
- RuvBL2 is involved in histone deacetylase inhibitor PCI-24781-induced cell death in SK-N-DZ neuroblastoma cells. | Zhan, Q., et al. 2013. PLoS One. 8: e71663. PMID: 23977108
- Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. | Hosokawa, H., et al. 2013. Proc Natl Acad Sci U S A. 110: 18626-31. PMID: 24167278
- Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases. | Rajendra, E., et al. 2014. Nucleic Acids Res. 42: 13736-48. PMID: 25428364
- RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer. | Yenerall, P., et al. 2020. Cell Chem Biol. 27: 105-121.e14. PMID: 31883965
- Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase. | Zimmermann, F., et al. 2020. Sci Adv. 6: PMID: 33355144
- Reptin/RUVBL2 is required for hepatocyte proliferation in vivo, liver regeneration and homeostasis. | Javary, J., et al. 2021. Liver Int. 41: 1423-1429. PMID: 33792165
- Unconventional tonicity-regulated nuclear trafficking of NFAT5 mediated by KPNB1, XPOT and RUVBL2. | Cheung, CY., et al. 2022. J Cell Sci. 135: PMID: 35635291
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Reptin 52 Antibody (D-6) | sc-374363 | 200 µg/ml | $322.00 | |||
Reptin 52 Antibody (D-6): m-IgGκ BP-HRP Bundle | sc-552026 | 200 µg Ab; 40 µg BP | $361.00 | |||
Reptin 52 Antibody (D-6) X | sc-374363 X | 200 µg/0.1 ml | $322.00 |