(R)-BEL CAS: 478288-90-3
MF: C16H13BrO2
MW: 317.18
An iPLA2γ inhibitor.

(R)-BEL (CAS 478288-90-3)

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Alternate Names: (R)-Bromoenol lactone
Application (R)-BEL is an iPLA2γ inhibitor
CAS 등록번호: 478288-90-3
순도: ≥98%
분자량: 317.18
분자식: C16H13BrO2
추가 정보: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

(R)-BEL is an irreversible, chiral, mechanism-based inhibitor of iPLA2γ (IC50 ~ 0.6 μM). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses (20-30 μM).


References

1. Balsinde, J., et al., 1999. Regulation and inhibition of phospholipase A2. Annual review of pharmacology and toxicology. 39(): 175-89. PMID: 10331081
2. Jenkins, Christopher M., et al., 2002. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. The Journal of biological chemistry. 277(36): 32807-14. PMID: 12089145

Formulation :
Solution in methyl acetate
Physical State :
Liquid
저장 :
Store at -20° C
비등점 :
~467.0° C at 760 mmHg (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1231, Class 3, Packing group II
PubChem CID :
SMILES :
C12=CC=CC=C1C(=CC=C2)[[email protected]]3CCC(OC3=O)=CC

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