Pyrimethamine CAS: 58-14-0
MF: C12H13ClN4
MW: 248.71
An inhibitor of P-glycoprotein and DHFR.

Pyrimethamine (CAS 58-14-0)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 123ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Alternate Names: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine; Daraprim
Application Pyrimethamine is an inhibitor of P-glycoprotein and DHFR
CAS 등록번호: 58-14-0
순도: ≥95%
분자량: 248.71
분자식: C12H13ClN4
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
loading

Pyrimethamine is a potent inhibitor of multi-drug and toxin extrusion transporters. This compound inhibits Mdr-1(P-glycoprotein) and thus allows for active drugs to stay within the cell for longer periods of time, increasing their effectiveness by preventing efflux of the active compound from the cytoplasm. Pyrimethamine also inhibits DHFR(dihydrofolate reductase ).


References

Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 12, 463 (1983), Leport, C., et al.: Am. J. Med., 84, 94 (1988), McIntosh, H.M., et al.: Ann. Trop. Med., Parasitol., 93, 265 (1998), Plowe, C.V., et al.: Br. Med. J., 328, 545 (2004),

Physical State :
Solid
용해도 :
Soluble in Ethanol (hot)
저장 :
Store at -20° C
녹는점 :
233-2340°C (lit.)
비등점 :
368.4° C at 760 mmHg
밀도 :
~1.4 g/cm3 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
SMILES :
CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl

SDS(MSDS)다운로드

분석증명서

PDF문서를 열람,
프린트와 코멘트를 작성하려면 Adobe Acrobat Reader가 필요합니다.

Pyrimethamine (CAS 58-14-0)  논문정보

다른 사용자의 Pyrimethamine (CAS 58-14-0)사용법보기. 클릭하여 PubMed entry보기 .

인용 1 to 1 of 1 합계

PMID: # 34193287  Sina, S.|Mohammad, JM.|Reza, S.|Anita, M.|Soudabeh, E.|Hadi, M.| et al. 2021. Eur J Med Res. 26: 65.

인용 1 to 1 of 1 합계
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 122ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 11ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;