PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt) MF: C41H78O22P4 4Na
MW: 1138.91

PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)

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분자량: 1138.91
분자식: C41H78O22P4 4Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Therefore, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates.


References

1. Lapetina, E.G., et al. 1981. Nature. 292: 367-369. PMID: 626579
2. Majerus, P.W. 1992. Annu. Rev. Biochem. 61: 225-250. PMID: 1323235
3. Tanaka, K., et al. 1997. Eur. J. Biochem. 245: 512-519. PMID: 9151987
4. Yang, X., et al. 1999. J. Biol. Chem. 274: 18973-18980. PMID: 10383396
5. Pike, L.J. and Casey, L. 1996. J. Biol. Chem. 271: 26453-26456. PMID: 8900109
6. Berridge, M.J. 1993. Nature. 361: 315-325. PMID: 8381210

Appearance :
Lyophilized powder
Physical State :
Solid
용해도 :
Soluble in PBS (pH 7.2) (~10 mg/ml). Sparingly soluble in organic solvents such as ethanol, DMSO, and DMF.
저장 :
Store at -20° C
굴절률 :
n20D 1.53 (Predicted)
Ki 데이타 :
RAC-alpha serine/threonine-protein kinase: Ki= 0.5 µM (mouse)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
SMILES :
[O-]P(OCC(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)(O[[email protected]@H]1[[email protected]](O)[[email protected]](OP([O-])(O)=O)[[email protected]@H](OP([O-])(O)=O)[[email protected]](OP([O-])(O)=O)[[email protected]]1O)=O

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