Proteasome Inhibitor VII, Antiprotealide MF: C12H18ClNO4
MW: 275.7
Inactivates the β5-subunit of the human 20S proteasome.

Proteasome Inhibitor VII, Antiprotealide

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Application Proteasome Inhibitor VII, Antiprotealide is which inactivates the β5-subunit of the human 20S proteasome
순도: ≥95%
분자량: 275.7
분자식: C12H18ClNO4
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).

Proteasome Inhibitor VII, Antiprotealide is a cell-permeable, Omuralide-Salinosporamide hybrid that irreversibly inactivates the β5-subunit of the human 20S proteasome. The compound has shown to be ~2.5-fold more potent than Omuralide and is expected to exhibit comparable whole cell potency to Salinosporamide A.


References

1. Reddy, Leleti Rajender., et al., 2005. An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition. Journal of the American Chemical Society. 127(25): 8974-6. PMID: 15969573

Physical State :
Solid
용해도 :
Soluble in DMSO.
저장 :
Store at -80° C
녹는점 :
194.33° C (Predicted)
비등점 :
484.69° C at 760 mmHg (Predicted)
밀도 :
1.31 g/cm3 (Predicted)
굴절률 :
n20D 1.53 (Predicted)
IC50 :
chymotrypsin-like activity of 20S proteasome: IC50 = 27 nM (rabbit ); trypsin-like activity of 20S proteasome: IC50 = 211 nM (rabbit); RPMI8226 cells: IC50 = 220 nM (human)
pK Values :
pKa: 13.27 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
SMILES :

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