Prostaglandin E2 Ethanolamide CAS: 194935-38-1
MF: C22H37NO5
MW: 395.5
An analog of PGE2 shown to bind EP1,2,3, &4 receptors and induce apoptosis in CRC cells.
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Prostaglandin E2 Ethanolamide (CAS 194935-38-1)

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Alternate Names: Dinoprostone Ethanolamide; PGE2-EA; Prostamide E2
Application Prostaglandin E2 Ethanolamide is an analog of PGE2 shown to bind EP1,2,3, &4 receptors and induce apoptosis in CRC cells
CAS 등록번호: 194935-38-1
분자량: 395.5
분자식: C22H37NO5
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).

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Prostaglandin E2 Ethanolamide is an analog of PGE2 (sc-201225) with improved water solubility and stability that has demonstrated the ability to induce apoptosis in HT29 and HCA7/C29 human colorectal carcinoma (CRC) cell lines. Shown to act as an agonist with all four known EP receptor subtypes (EP1 - EP4), but with an affinity that is significantly less than PGE2. This compound is thought to be biosyntesized via COX-2 from the precursor anandamide (sc-200790; N-arachidonoylethanolamide), the endogenous cannabinoid neurotransmitter. These prostaglandin analogues are integral for structure-activity studies used in the deconvolution of these complex biochemical pathways, and in this case demonstrates unique and applicable biochemical activity.


References

1. Yu, M., et al. 1997. J. Biol. Chem. 272: 21181-21186. PMID: 9261124
2. Ross, R.A., et al. 2002. J. Pharmacol. Exp. Ther. 301: 900-907. PMID: 12023517
3. Weber, A., et al. 2004. J. Lipid Res. 45: 757-763. PMID: 14729864
4. Patsos, H.A., et al. 2005. Gut. 54: 1741-1750. PMID: 16099783
5. Glass, M., et al. 2005. J. Lipid Res. 46: 1364-1368. PMID: 15863842
6. Correa, F., et al. 2008. Biochem. J. 409: 761-770. PMID: 17961121

Physical State :
Solid
저장 :
Store at -20° C
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
5283119
SMILES :
CCCCC[[email protected]@H](/C=C/[[email protected]]1[[email protected]@H](CC(=O)[[email protected]@H]1C/C=C\\CCCC(=O)NCCO)O)O

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