Probucol CAS: 23288-49-5
MF: C31H48O2S2
MW: 516.84
An antioxidant, anti-inflammatory, and hypocholesterolemic agent which inhibits atherogenesis in murine models.

Probucol (CAS 23288-49-5)

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Alternate Names: Bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole acetone
Application Probucol is an antioxidant, anti-inflammatory, and hypocholesterolemic agent which inhibits atherogenesis in murine models
CAS 등록번호: 23288-49-5
순도: ≥98%
분자량: 516.84
분자식: C31H48O2S2
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

Probucol is an antioxidant, antiinflammatory and hypocholesterolemic agent. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis. Lowers serum cholesterol by increasing low-density lipoprotein (LDL) catabolism in the final metabolic pathway for cholesterol elimination.


References

1. Ku, G., et al. 1990. FASEB J. 4: 1645-1653.
2. Ruixing,Y., et al. 2006. Scand. J. Clin. Lab. Invest. 66: 549-558.
3. Wu, B.J., et al. 2007. J. Pharmacol. Exp. Ther. 321: 477-488.

Appearance :
Powder
Physical State :
Solid
용해도 :
Soluble in DMSO (25 mM), ethanol (100 mM), water (partly), and chloroform.
저장 :
Store at room temperature
녹는점 :
126-128° C
비등점 :
546.69° C at 760 mmHg (Predicted)
밀도 :
1.08 g/cm3 (Predicted)
굴절률 :
n20D 1.57 (Predicted)
IC50 :
Sus scrofa: IC50 = 0.5 µM; Plasma: IC50 = 1.3 µM (human); human cell lines: IC50 = 2.8 µM; 15-LO: IC50 = 14 µM (human)
pK Values :
pKa: 10.27 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
2
RTECS :
AL3705000
PubChem CID :
Merck Index :
12: 7935
MDL Number :
MFCD00079281
EC Number :
245-560-9
Beilstein Registry :
2026253
SMILES :
CC(C)(SC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C)SC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C

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분석증명서

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Probucol (CAS 23288-49-5)  논문정보

다른 사용자의 Probucol (CAS 23288-49-5)사용법보기. 클릭하여 PubMed entry보기 .

인용 1 to 4 of 4 합계

PMID: # 31011926  Zucoloto, AZ. et al. 2019. Inflammation.

PMID: # 28386622  Zucoloto, AZ. et al. 2017. Inflamm. Res. 66: 591-602.

PMID: # 28892789  Biomed. Pharmacother. 780-788.

PMID: # 28501577  Eur J Pharmacol. 52-63.

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