Pitavastatin Calcium CAS: 147526-32-7
MF: C50H46CaF2N2O8
MW: 880.98
A competitive inhibitor of HMG-CoA reductase.

Pitavastatin Calcium (CAS 147526-32-7)

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Pitavastatin Calcium is rated 5.0 out of 5 by 2.
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Alternate Names: Pitavastatin hemicalcium; Nisvastatin
Application Pitavastatin Calcium is a competitive inhibitor of HMG-CoA reductase
CAS 등록번호: 147526-32-7
순도: ≥98%
분자량: 880.98
분자식: C50H46CaF2N2O8
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).

Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox (NADPH oxidase). In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187 (sc-3591). Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells.


References

1. Kajinami, K., et al. 2003. Cardiovasc Drug Rev. 21: 199-215. PMID: 12931254
2. Terata, Y., et al. 2003. Pharmacology. 68: 169-176. PMID: 12837970
3. Hayashi, T., et al. 2004. Atherosclerosis. 176: 255-263. PMID: 15380447
4. Takayama, T., et al. 2004. Circ. J. 68: 1067-1075. PMID: 15502390

Appearance :
Powder
Physical State :
Solid
용해도 :
Soluble in DMSO (100 mMl), water (<1 mg/ml), and ethanol (<1 mg/ml).
저장 :
Store at room temperature
비등점 :
692° C at 760 mmHg
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
5282451
SMILES :
O[[email protected]](/C=C/c1c(nc2ccccc2c1c1ccc(F)cc1)C1CC1)C[[email protected]@H](O)CC(=O)O[Ca]OC(=O)C[[email protected]](O)C[[email protected]](O)/C=C/c1c(nc2ccccc2c1c1ccc(F)cc1)C1CC1

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Pitavastatin Calcium (CAS 147526-32-7)  논문정보

다른 사용자의 Pitavastatin Calcium (CAS 147526-32-7)사용법보기. 클릭하여 PubMed entry보기 .

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PMID: # 25993292  Yoshimura, K. et al. 2015. Int J Mol Sci. 16: 11213-28.

PMID: # 24671957  Chang, JH. et al. 2014. Drug Metab. Dispos. 42: 1067-73.

PMID: # 23750830  Chang, JH. et al. 2013. Mol. Pharm. 10: 3067-75.

PMID: # 23564645  Zhang, X. et al. 2013. Toxicological sciences : an official journal of the Society of Toxicology. 134: 73-82.

PMID: # 31772607  Cardiovasc Ther. 2019: 2549432.

PMID: # 31527323  J. Atheroscler. Thromb. 27: 429-440.

PMID: # 32435188  Front Pharmacol. 469.

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