Phenylmethylsulfonyl Fluoride (CAS 329-98-6)
Phenylmethylsulfonyl Fluoride (PMSF) is an irreversible inhibitor of serine proteases, such as trypsin, chymotrypsin and thrombin. Phenylmethylsulfonyl Fluoride affords alkenes by reacting with carbonyl compounds and causes sulfonylation of the active-site serine residues. Phenylmethylsulfonyl Fluoride (PMSF) also inhibits most cysteine proteases like papain. Phenylmethylsulfonyl Fluoride is commonly used in the preparation of cell lysates to inhibit protein digestion. Phenylmethylsulfonyl Fluoride can substitute for diisopropylfluorophosphate (DFP) (sc-203922). Phenylmethylsulfonyl Fluoride also inhibits metalloproteases and aspartic proteases. Phenylmethylsulfonyl Fluoride is a widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity.
References
1. Tsang, V.C., et al. 1989. J. Infect. Dis. 159: 50-59. PMID: 2909643
2. Nam, K.H., et al. 2009. Biochem. Biophys. Res. Commun. 389: 247-250. PMID: 19715665
3. Krishnan, N., et al. 2009. J. Biol. Chem. 284: 16066-16070. PMID: 19351884
SDS(MSDS)다운로드
분석증명서
PDF문서를 열람,
프린트와 코멘트를 작성하려면 Adobe Acrobat Reader가 필요합니다.
Phenylmethylsulfonyl Fluoride (CAS 329-98-6) 논문정보
다른 사용자의 Phenylmethylsulfonyl Fluoride (CAS 329-98-6)사용법보기. 클릭하여 PubMed entry보기 .
PMID: 36433049 | Surface Modification of Electrospun Bioresorbable and Biostable Scaffolds by Pulsed DC Magnetron Sputtering of Titanium for Gingival Tissue Regeneration. | Badaraev, AD. et al. 2022. Polymers (Basel). 14: 1791-1804.
PMID: 35189699 | Y-Box Binding Protein 1 Interacts with Dengue Virus Nucleocapsid and Mediates Viral Assembly. | Diosa-Toro, M. et al. 2022. mBio. e0019622.
PMID: 35670811 | Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency. | Campbell, TM. et al. 2022. J Exp Med. 219:
PMID: 36416565 | Aging and endothelium-mediated vascular dysfunction: the role of the NADPH oxidases. | Kwon, OS. et al. 2022. J Physiol.
PMID: 33913241 | Vanadium oxides modify the expression levels of the p21, p53, and Cdc25C proteins in human lymphocytes treated in vitro. | Mateos-Nava, RA. et al. 2021. Environ Toxicol.
PMID: 33558531 | The GSK3β-β-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a. | Ye, Z. et al. 2021. NPJ Aging Mech Dis. 7: 4.
PMID: 33808034 | Trans-Epithelial Transport, Metabolism, and Biological Activity Assessment of the Multi-Target Lupin Peptide LILPKHSDAD (P5) and Its Metabolite LPKHSDAD (P5-Met). | Lammi, C. et al. 2021. Nutrients. 13:
PMID: 32979866 | Inflammatory pain in peripheral tissue depends on the activation of the TNF-α type 1 receptor in the primary afferent neuron. | de Magalhães, SF. et al. 2021. Eur J Neurosci. 53: 376-389.
PMID: 33569384 | Deficiency of Rbpj Leads to Defective Stress-Induced Hematopoietic Stem Cell Functions and Hif Mediated Activation of Non-canonical Notch Signaling Pathways. | Lakhan, R. et al. 2020. Front Cell Dev Biol. 8: 622190.
PMID: 30389374 | Neurite atrophy and apoptosis mediated by PERK signaling after accumulation of GM2-ganglioside. | Virgolini, MJ. et al. 2019. Biochim Biophys Acta Mol Cell Res. 1866: 225-239.