Phenylmethylsulfonyl Fluoride CAS: 329-98-6
MF: C7H7FO2S
MW: 174.19

Phenylmethylsulfonyl Fluoride (CAS 329-98-6)

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Alternate Names: Phenylmethylsulfonyl Fluoride is also known as PMSF.
Application Phenylmethylsulfonyl Fluoride is an irreversible serine protease, cysteine protease, and FAAH inhibitor.
CAS 등록번호: 329-98-6
순도: ≥99%
분자량: 174.19
분자식: C7H7FO2S
추가 정보: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Phenylmethylsulfonyl Fluoride (PMSF) is an irreversible inhibitor of serine proteases, such as trypsin, chymotrypsin and thrombin. Phenylmethylsulfonyl Fluoride affords alkenes by reacting with carbonyl compounds and causes sulfonylation of the active-site serine residues. Phenylmethylsulfonyl Fluoride (PMSF) also inhibits most cysteine proteases like papain. Phenylmethylsulfonyl Fluoride is commonly used in the preparation of cell lysates to inhibit protein digestion. Phenylmethylsulfonyl Fluoride can substitute for diisopropylfluorophosphate (DFP) (sc-203922). Phenylmethylsulfonyl Fluoride also inhibits metalloproteases and aspartic proteases. Phenylmethylsulfonyl Fluoride is a widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity.


References

1. Tsang, V.C., et al. 1989. J. Infect. Dis. 159: 50-59. PMID: 2909643

2. Nam, K.H., et al. 2009. Biochem. Biophys. Res. Commun. 389: 247-250. PMID: 19715665

3. Krishnan, N., et al. 2009. J. Biol. Chem. 284: 16066-16070. PMID: 19351884

Appearance :
Powder
Physical State :
Solid
용해도 :
Soluble in ether, benzene, (anhydrous 2-propanol (200 mM), anhydrous methanol (200 mM), anhydrous ethanol (200 mM),Stock solution are stable for months at 4°C) water(unstable), and toluene.
저장 :
Store at 4° C
녹는점 :
92-94° C
비등점 :
85° C (lit.) at 0.3 mmHg
밀도 :
~1.3 g/cm3 (Predicted)
굴절률 :
n20D 1.52 (Predicted)
IC50 :
Anandamide amidohydrolase: IC50 = 13 µM (human); Leukocyte elastase: IC50 = 52.2 µM (human)
Ki 데이타 :
chymotrypsin : Ki= 13 µM
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
XT8040000
PubChem CID :
Merck Index :
14: 7542
MDL Number :
MFCD00007424
EC Number :
206-350-2
Beilstein Registry :
2088311
SMILES :
C1=CC=C(C=C1)CS(=O)(=O)F

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Phenylmethylsulfonyl Fluoride (CAS 329-98-6)  논문정보

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PMID: # 35189699  Diosa-Toro, M.|Kennedy, DR.|Chuo, V.|Popov, VL.|Pompon, J.|Garcia-Blanco, MA.| et al. 2022. mBio. e0019622.

PMID: # 35670811  Campbell, TM.|Liu, Z.|Zhang, Q.|Moncada-Velez, M.|Covill, LE.|Zhang, P.|Alavi Darazam, I.|Bastard, P.|Bizien, L.|Bucciol, G.|Lind Enoksson, S.|Jouanguy, E.|Karabela, ŞN.|Khan, T.|Kendir-Demirkol, Y.|Arias, AA.|Mansouri, D.|Marits, P.|Marr, N.|Migeotte, I.|Moens, L.|Ozcelik, T.|Pellier, I.|Sendel, A.|Shahrooei, M.|Smith, CIE.|Vandernoot, I.|Willekens, K.|, .|Bergman, P.|Abel, L.|Cobat, A.|Casanova, JL.|Meyts, I.|Bryceson, YT.| et al. 2022. J Exp Med. 219:

PMID: # 36416565  Kwon, OS.|Noh, SG.|Park, SH.|Andtbacka, RHI.|Hyngstrom, JR.|Richardson, RS.| et al. 2022. J Physiol.

PMID: # 33913241  Mateos-Nava, RA.|Rodríguez-Mercado, JJ.|Álvarez-Barrera, L.|García-Rodríguez, MDC.|Altamirano-Lozano, MA.| et al. 2021. Environ Toxicol.

PMID: # 33558531  Ye, Z.|Gould, TM.|Zhang, H.|Jin, J.|Weyand, CM.|Goronzy, JJ.| et al. 2021. NPJ Aging Mech Dis. 7: 4.

PMID: # 33808034  Lammi, C.|Aiello, G.|Bollati, C.|Li, J.|Bartolomei, M.|Ranaldi, G.|Ferruzza, S.|Fassi, EMA.|Grazioso, G.|Sambuy, Y.|Arnoldi, A.| et al. 2021. Nutrients. 13:

PMID: # 32979866  de Magalhães, SF.|Manzo, LP.|de Faria, FM.|de Oliveira-Fusaro, MC.|Nishijima, CM.|Vieira, WF.|Bonet, IJM.|Dos Santos, GG.|Tambeli, CH.|Parada, CA.| et al. 2021. Eur J Neurosci. 53: 376-389.

PMID: # 33569384  Lakhan, R.|Rathinam, CV.| et al. 2020. Front Cell Dev Biol. 8: 622190.

PMID: # 30690728  Kwon, OS.|Andtbacka, RHI.|Hyngstrom, JR.|Richardson, RS.| et al. 2019. J Physiol. 597: 1791-1804.

PMID: # 30389374  Virgolini, MJ.|Feliziani, C.|Cambiasso, MJ.|Lopez, PH.|Bollo, M.| et al. 2019. Biochim Biophys Acta Mol Cell Res. 1866: 225-239.

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