Perphenazine CAS: 58-39-9
MF: C21H26ClN3OS
MW: 403.97
Perphenazine is a D2DR inhibitor.

Perphenazine (CAS 58-39-9)

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Application Perphenazine is a D2DR inhibitor
CAS 등록번호: 58-39-9
순도: ≥99%
분자량: 403.97
분자식: C21H26ClN3OS
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* 참조분석증명서대량의 측정 데이터(함수량포함).

Perphenazine is a D2DR inhibitor which inhibits the glutamate dehydrogenase in vitro. Perphenazine also acts as a α-adrenergic receptor antagonist and σ-receptor agonist. Studies indicate that uncharged Perphenazine is better at forming complexes with cyclodextrins. In addition, Perphenazine forms more stable complexes with cyclodextrins than fluphenazine (sc-205700). Studies show that Perphenazine enhances the expression of CD71 on K562 cells, while at the same time inhibiting the proliferation of these cells.


References

1. Lutka, A. and Prange, W. 2005. Acta Pol Pharm. 62(6): 419-425. PMID: 16583980

2. Yuan, L.B. and He, Q. 2005. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 30(3): 288-291. PMID: 16045015

Physical State :
Solid
용해도 :
Soluble in ethanol (50 mg/ml), water (0.028 mg/ml at 24° C), methanol, and chloroform.
저장 :
Store at 4° C
녹는점 :
97° C (lit.)
비등점 :
580.4° C at 760 mmHg
밀도 :
~1.3 g/cm3 (Predicted)
굴절률 :
n20D 1.63 (Predicted)
IC50 :
AOX1: IC50 = 33 nM (human); Aldehyde oxidase: IC50 = 740 nM (rat); Pleiotropic ABC efflux transporter of multiple drugs: IC50 = 1.4 µM (Saccharomyces cerevisiae S288c); Plasmodium falciparum: IC50 = 2.51 µM; HERG: IC50 = 4.22 µM (human)
Ki 데이타 :
SR-7: Ki= 23 nM (human); HERG: Ki= 3.45 µM (human)
pK Values :
pKa: 7.39, pKb: 7.94 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
4748
Merck Index :
14: 7183
MDL Number :
MFCD00056798
EC Number :
200-381-5
SMILES :
C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO

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분석증명서

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