Perillic Acid CAS: 23635-14-5
MF: C10H14O2
MW: 166.22
An apoptosis inducing agent via an increase in p21, Bax, and caspase-3 in cells.

Perillic Acid (CAS 23635-14-5)

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Synonym: (S)-4-(1-Methylethenyl)-1-cyclohexene-1-carboxylic acid
Application An apoptosis inducing agent via an increase in p21, Bax, and caspase-3 in cells
CAS 등록번호: 23635-14-5
순도: 95%
분자량: 166.22
분자식: C10H14O2
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Perillic Acid, a metabolite of perillyl alcohol, has been shown to elicit cytotoxicity, induce cell cycle arrest and apoptosis via an increase in expression of p21, Bax, and caspase-3 activity in cells. This compound has also been found to be a major metabolite of d-limonene (sc-205283), a solvent of cholesterol. Perillic Acid has been noted to inhibit isoprenylation. Studies suggest that this agent has demonstrated the capacity to produce morphological changes to murine lens epithelial cells in culture and cause opacification of the lenses.


References

1. Cheng, Q.F., et al. 2001. Exp. Eye Res. 73: 239-245. PMID: 11446774
2. Chow, H.H., et al. 2002. Cancer Epidemiol. Biomarkers Prev. 11: 1472-1476. PMID: 12433729
3. Yeruva, L., et al. 2007. Cancer Lett. 257: 216-226. PMID: 17888568

Physical State :
Solid
용해도 :
Soluble in DMSO, and ethanol.
저장 :
Store at 4° C
녹는점 :
129-131° C (lit.)
비등점 :
284.94° C at 760 mmHg
밀도 :
1.07 g/cm3
굴절률 :
n20D 1.51
Optical Activity :
α20/D -102°, c = 2 in methanol
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
2724160
MDL Number :
MFCD00062539
EC Number :
231-709-5
SMILES :
CC(=C)[[email protected]]1CCC(=CC1)C(=O)O

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