PDGF Receptor beta/PDGFRB Antibody (18A2): sc-19995

PDGFR-β Antibody (18A2) is a mouse monoclonal IgG1 kappa light chain antibody that detects PDGF receptor type β of human origin by immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). PDGFR-β monoclonal antibody (18A2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The platelet-derived growth factor (PDGF) receptor type β plays a crucial role in cell signaling, particularly in the regulation of cell growth, survival, and migration, which are vital processes in tissue repair and development. PDGFR-β is primarily located on the surface of mesenchymal and glial cells, where PDGFR-β mediates the effects of its ligand, PDGF-BB, leading to receptor dimerization and activation of downstream signaling pathways. PDGFR-β′s ability to bind specifically to the B subunit of PDGF is essential for its function, as PDGFR-β triggers a cascade of intracellular events that influence cellular behavior. Dysregulation of PDGFR-β signaling has been implicated in various pathologies, including chronic myelomonocytic leukemia (CMML), highlighting PDGFR-β′s importance as a therapeutic target in cancer treatment.

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PDGF Receptor beta/PDGFRB Antibody (18A2) References:

1. Erythropoietin production by PDGFR-β(+) cells.  |  Gerl, K., et al. 2016. Pflugers Arch. 468: 1479-87. PMID: 27220347
2. PDGFR-β restores blood-brain barrier functions in a mouse model of focal cerebral ischemia.  |  Shen, J., et al. 2019. J Cereb Blood Flow Metab. 39: 1501-1515. PMID: 29629621
3. The role of PDGF-B/PDGFR-BETA axis in the normal development and carcinogenesis of the breast.  |  Jitariu, AA., et al. 2018. Crit Rev Oncol Hematol. 131: 46-52. PMID: 30293705
4. PDGFR-β Signaling Regulates Cardiomyocyte Proliferation and Myocardial Regeneration.  |  Yue, Z., et al. 2019. Cell Rep. 28: 966-978.e4. PMID: 31340157
5. Dysregulated mesenchymal PDGFR-β drives kidney fibrosis.  |  Buhl, EM., et al. 2020. EMBO Mol Med. 12: e11021. PMID: 31943786
6. PDGFR-β+ fibroblasts deteriorate survival in human solid tumors: a meta-analysis.  |  Hu, G., et al. 2021. Aging (Albany NY). 13: 13693-13707. PMID: 33946048
7. Cancer-Associated Fibroblasts Promote Lymphatic Metastasis in Cholangiocarcinoma via the PDGF-BB/PDGFR-β Mediated Paracrine Signaling Network.  |  Yan, J., et al. 2024. Aging Dis. 15: 369-389. PMID: 37307823
8. Inhibition of PDGFRβ alleviates endothelial cell apoptotic injury caused by DRP-1 overexpression and mitochondria fusion failure after mitophagy.  |  An, X., et al. 2023. Cell Death Dis. 14: 756. PMID: 37980402
9. Targeting endothelial PDGFR-β facilitates angiogenesis-associated bone formation through the PAK1/NICD axis.  |  Lin, H., et al. 2024. J Cell Physiol. 239: e31291. PMID: 38721633
10. Macrophage-derived PDGF-BB modulates glycolytic enzymes expression and pyroptosis in nucleus pulposus cells via PDGFR-β/TXNIP pathway.  |  Zheng, X., et al. 2024. Osteoarthritis Cartilage. 32: 1245-1260. PMID: 38744373

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PDGF Receptor beta/PDGFRB Antibody (18A2) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-PDGF Receptor beta/PDGFRB Antibody (18A2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PDGF Receptor beta/PDGFRB Antibody (18A2) Specifications

Alternate Product Name: PDGFRB

Product Clone Name: 18A2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: PDGFR-β

Epitope Species: human

Product Reactivity/Detection: PDGF receptor type β

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of KAPPA!!

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for PDGF Receptor beta/PDGFRB Antibody (18A2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred PDGF Receptor beta/PDGFRB antibody is PDGF Receptor beta/PDGFRB Antibody (D-6): sc-374573.