PD 166285 CAS: 212391-63-4
MF: C26H27Cl2N5O2•2HCl
MW: 585.35
An inhibitor of RTK, c-Src, FGFR1, Wee 1, and PDGFRβ.

PD 166285 (CAS 212391-63-4)

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Alternate Names: Heparin-Cantithrombin II
Application PD 166285 is an inhibitor of RTK, c-Src, FGFR1, Wee 1, and PDGFRβ
CAS 등록번호: 212391-63-4
순도: ≥98%
분자량: 585.35
분자식: C26H27Cl2N5O22HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

PD 166285 is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1), and PDGFRβ (platelet-derived growth factor receptor β) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). PD 166285 also inhibits the checkpoint kinases Wee1 and MYT1 (Myt1), abolishes Cdc2 phosphorylation in numerous tumor cell lines, and abrogates the G2 checkpoint. PD 166285 is an RTK inhibitor with broad-spectrum properties and displays anti-angiogenic activity and anti-tumor efficacy when used with PDT (photodynamic therapy). PD 166285 is an inhibitor of EGFR.


References

Star, W., et al.: Cancer Res., 46, 2532 (1986), Sawutz, D., et al.: Biochem. Pharm., 51, 1631 (1996), Voest, E., et al.: Anti-Cancer Drugs, 7, 723 (1996), Connolly, C., et al.: Bioorg. Med. Chem. Lett., 7(18), 2415 (1997), Hamby, J., et al.: J. Med. Chem., 40, 2296 (1997)

Physical State :
Solid
용해도 :
Soluble in water, methanol, and DMSO (100 mM).
저장 :
Store at 4° C
녹는점 :
236-241° C
굴절률 :
n20D ~1.64 (Predicted)
IC50 :
c-Src: IC50 = 8.4 nM; Wee 1: IC50 = 24 nM; Flg: IC50 = 39.3 nM; MYT1: IC50 = 72 nM; EGFR: IC50 = 87.5 nM
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
9916391
MDL Number :
MFCD18086890
SMILES :
CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl.Cl.Cl

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PD 166285 (CAS 212391-63-4)  논문정보

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PMID: # 29941193  Platzer, C.|Najjar, A.|Rohe, A.|Erdmann, F.|Sippl, W.|Schmidt, M.| et al. 2018. Bioorg Med Chem. 26: 4014-4024.

PMID: # 24229357  Rohe, A. et al. 2014. Assay Drug Dev Technol. 12: 136-44.

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