PC-TP Antibody (LB-6): sc-101309

PC-TP Antibody (LB-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects PC-TP protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PC-TP antibody (LB-6) is available as the non-conjugated form. PC-TP protein, also known as StARD2, plays a crucial role in phosphatidylcholine (PC) transport between cellular membranes, which is essential for maintaining membrane integrity and fluidity. PC-TP (LB-6) monoclonal antibody targets a protein primarily located in the cytosol and highly expressed in tissues such as liver, placenta, testis, kidney, and heart, while exhibiting lower levels in brain and lung. PC-TP′s ability to facilitate intermembrane transfer of phospholipids is vital for various cellular processes, including lipid metabolism and signaling pathways. Studies involving Pctp knockout mice have shown that PC-TP absence does not significantly affect PC secretion into bile or lung surfactant, suggesting other mechanisms may compensate for these processes. PC-TP (LB-6) antibody recognizes a protein encoded by a gene located on human chromosome 17q21-q24, highlighting genetic significance. With specific reactivity and versatile applications, anti-PC-TP antibody (LB-6) serves as an invaluable tool for researchers studying lipid transport and metabolism in human tissues.

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PC-TP Antibody (LB-6) References:

1. Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces.  |  van Helvoort, A., et al. 1999. Proc Natl Acad Sci U S A. 96: 11501-6. PMID: 10500206
2. Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein.  |  Cohen, DE., et al. 1999. Biochim Biophys Acta. 1447: 265-70. PMID: 10542325
3. Determination of the stability of the noncovalent phospholipid transfer protein-lipid complex by electrospray time-of-flight mass spectrometry.  |  de Brouwer, AP., et al. 2002. Biochemistry. 41: 8013-8. PMID: 12069592
4. Phospholipid transfer proteins: from lipid monolayers to cells.  |  Wirtz, KW. 1991. Klin Wochenschr. 69: 105-11. PMID: 2013970

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PC-TP Antibody (LB-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PC-TP Antibody (LB-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PC-TP Antibody (LB-6) Specifications

Alternate Product Name: PC-TP

Product Clone Name: LB-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-215

Epitope Target: PC-TP

Epitope Species: human

Product Reactivity/Detection: PC-TP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PC-TP Antibody (LB-6): N/A