Paroxetine HCl CAS: 78246-49-8
MF: C19H20FNO3•HCl
MW: 365.82
A highly potent and selective serotonin (5-HT) uptake inhibitor.

Paroxetine HCl (CAS 78246-49-8)

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Alternate Names: Paroxat
Application Paroxetine HCl is a highly potent and selective serotonin (5-HT) uptake inhibitor
CAS 등록번호: 78246-49-8
순도: ≥98%
분자량: 365.82
분자식: C19H20FNO3•HCl
추가 정보: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

Paroxetine HCl, a phenylpiperidine derivative, is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity (Ki = 05 nM). In vitro paroxetine competitively inhibits the uptake of 5-HT by rat hypothalamic and cortical synaptosomes with only very weak inhibitory effects on SLC6A2 (noradrenaline) uptake and DAT (dopamine) uptake. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors. Other experiments have shown Paroxetine HCl to inhibit NOS (nitric oxide synthase) and also to be both a substrate and an inhibitor of CYP2D6 (cytochrome isoenzyme P450 2D6).


References

1. Thomas, D.R., et al. 1987. Psychopharmacology. 93: 193-200. PMID: 2962217
2. Owens, M.J., et al. 1997. J. Pharmacol. Exp. Ther. 283: 1305-1322. PMID: 9400006
3. Bourin, M., et al. 2001. CNS Drug Rev. 7: 25-47. PMID: 11420571
4. Fujishiro, J., et al. 2002. Eur. J. Pharmacol. 454: 183-188. PMID: 12421645

Physical State :
Solid
용해도 :
Soluble in DMSO (25 mg/ml), chloroform, and methanol. Insoluble in water.
저장 :
Store at room temperature
녹는점 :
137-139° C
Ki 데이타 :
serotonin transporter : Ki= 0.05 nM; muscarinic Ach receptors: Ki= 42 nM
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
RTECS :
TM4569300
PubChem CID :
Merck Index :
14: 7043
SMILES :
C1CNC[[email protected]]([[email protected]@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl

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Paroxetine HCl (CAS 78246-49-8)  논문정보

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PMID: # 27288589  Saroja, SR.|Aher, YD.|Kalaba, P.|Aher, NY.|Zehl, M.|Korz, V.|Subramaniyan, S.|Miklosi, AG.|Zanon, L.|Neuhaus, W.|Höger, H.|Langer, T.|Urban, E.|Leban, J.|Lubec, G.| et al. 2016. Behav. Brain Res. 312: 127-37.

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