Paroxetine HCl (CAS 78246-49-8)
Paroxetine HCl, a phenylpiperidine derivative, is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity (Ki = 05 nM). In vitro paroxetine competitively inhibits the uptake of 5-HT by rat hypothalamic and cortical synaptosomes with only very weak inhibitory effects on SLC6A2 (noradrenaline) uptake and DAT (dopamine) uptake. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors. Other experiments have shown Paroxetine HCl to inhibit NOS (nitric oxide synthase) and also to be both a substrate and an inhibitor of CYP2D6 (cytochrome isoenzyme P450 2D6).
References
1. Thomas, D.R., et al. 1987. Psychopharmacology. 93: 193-200. PMID: 2962217
2. Owens, M.J., et al. 1997. J. Pharmacol. Exp. Ther. 283: 1305-1322. PMID: 9400006
3. Bourin, M., et al. 2001. CNS Drug Rev. 7: 25-47. PMID: 11420571
4. Fujishiro, J., et al. 2002. Eur. J. Pharmacol. 454: 183-188. PMID: 12421645
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PMID: # 27288589 Saroja, SR.|Aher, YD.|Kalaba, P.|Aher, NY.|Zehl, M.|Korz, V.|Subramaniyan, S.|Miklosi, AG.|Zanon, L.|Neuhaus, W.|Höger, H.|Langer, T.|Urban, E.|Leban, J.|Lubec, G.| et al. 2016. Behav. Brain Res. 312: 127-37.