p-p120 Antibody (pY291.15A): sc-136475

p-p120 Antibody (pY291.15A) is a mouse monoclonal IgG1 antibody that detects p120 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p120, also known as cadherin-associated Src substrate, is a crucial protein that plays a significant role in cellular adhesion by interacting with E-cadherin and other catenins. p120 is primarily located in the cytoplasm, nucleus, and cell membrane of vascular endothelial cells, which is vital for mediating cell signaling and maintaining tissue integrity. p120′s presence in these cellular compartments allows participation in ligand-induced receptor signaling pathways involving epidermal growth factor, platelet-derived growth factor, colony-stimulating factor-1, and Neu receptors, thereby influencing various cellular processes such as proliferation and differentiation. p120 exhibits structural complexity with four major isoforms resulting from alternative splicing, and contains ten ARM repeats that contribute to interactions with other proteins. p120 undergoes phosphorylation after translation, which can modulate activity and interactions, making p120 a key player in the regulation of cadherin-mediated adhesion and signaling pathways.

The preferred p120 antibody is p120 Antibody (15D2): sc-23872.