Molecular structure of Oxotremorine M, CAS Number: 63939-65-1
Oxotremorine M (CAS 63939-65-1)
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Alternate Names:
Oxotremorine Methiodide; N,N,N,-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-ammonium iodide
Application:
Oxotremorine M is a small molecule agonist of muscarinic receptors
CAS Number:
63939-65-1
Purity:
≥98%
Molecular Weight:
322.19
Molecular Formula:
C11H19IN2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Oxotremorine M is a muscarinic receptor agonist that activates both M2 and M3 subtypes of muscarinic receptors. It is a potent cholinergic agonist that stimulates the parasympathetic nervous system by mimicking the action of acetylcholine. Oxotremorine M binds to muscarinic receptors in various tissues, including smooth muscle, cardiac muscle, and exocrine glands, leading to a range of physiological responses. Oxotremorine M is used to study the role of muscarinic receptors in different biological processes. It modulates neurotransmitter release and synaptic transmission, providing insights into the mechanisms of neuronal communication. Oxotremorine M is for investigating the function of muscarinic receptors and their role in various physiological and pathological conditions.
Oxotremorine M (CAS 63939-65-1) References
- Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M. | Dallanoce, C., et al. 1999. Bioorg Med Chem. 7: 1539-47. PMID: 10482446
- Heterogeneity of release-inhibiting muscarinic autoreceptors in heart atria and urinary bladder: a study with M(2)- and M(4)-receptor-deficient mice. | Zhou, H., et al. 2002. Naunyn Schmiedebergs Arch Pharmacol. 365: 112-22. PMID: 11819029
- New analogues of oxotremorine and oxotremorine-M: estimation of their in vitro affinity and efficacy at muscarinic receptor subtypes. | Barocelli, E., et al. 2000. Life Sci. 67: 717-23. PMID: 12659177
- Role of cholinergic receptors in locomotion induced by scopolamine and oxotremorine-M. | Chintoh, A., et al. 2003. Pharmacol Biochem Behav. 76: 53-61. PMID: 13679217
- M2, M3, and M4 receptor subtypes contribute to muscarinic potentiation of GABAergic inputs to spinal dorsal horn neurons. | Zhang, HM., et al. 2005. J Pharmacol Exp Ther. 313: 697-704. PMID: 15640398
- Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels. | Winks, JS., et al. 2005. J Neurosci. 25: 3400-13. PMID: 15800195
- Dynamic regulation of glycinergic input to spinal dorsal horn neurones by muscarinic receptor subtypes in rats. | Wang, XL., et al. 2006. J Physiol. 571: 403-13. PMID: 16410279
- Regulation of glutamate release from primary afferents and interneurons in the spinal cord by muscarinic receptor subtypes. | Zhang, HM., et al. 2007. J Neurophysiol. 97: 102-9. PMID: 17050831
- Impaired M3 and enhanced M2 muscarinic receptor contractile function in a streptozotocin model of mouse diabetic urinary bladder. | Pak, KJ., et al. 2010. Naunyn Schmiedebergs Arch Pharmacol. 381: 441-54. PMID: 20349044
- A novel muscarinic receptor-independent mechanism of KCNQ2/3 potassium channel blockade by Oxotremorine-M. | Zwart, R., et al. 2016. Eur J Pharmacol. 791: 221-228. PMID: 27590358
- Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms. | Zwart, R., et al. 2018. Biochem Biophys Res Commun. 495: 481-486. PMID: 29127015
- Neuroprotective and Antioxidant Role of Oxotremorine-M, a Non-selective Muscarinic Acetylcholine Receptors Agonist, in a Cellular Model of Alzheimer Disease. | Nuzzo, D., et al. 2022. Cell Mol Neurobiol.. PMID: 36056992
- The binding of agonists to brain muscarinic receptors. | Birdsall, NJ., et al. 1978. Mol Pharmacol. 14: 723-36. PMID: 714021
- Oxotremorine-M activates single nicotinic acetylcholine receptor channels in cultured Xenopus myocytes. | Reitstetter, R., et al. 1994. Eur J Pharmacol. 264: 27-32. PMID: 7530203
- Functional properties of muscarinic receptor subtypes Hm1, Hm3 and Hm5 expressed in Sf9 cells using the baculovirus expression system. | Kukkonen, JP., et al. 1996. J Pharmacol Exp Ther. 279: 593-601. PMID: 8930161
Inhibitor of:
ChoKB.Activator of:
γENaC, AChRα1, AChRδ, D-type cyclin, EMR2, ITF, KLHL12, KLHL34, mAChR M, mAChR M2, mAChR M3, myomegalin, RGS8, Vmn1r30, Vmn2r53, Vmn2r55, Vmn2r57, Vmn2r59, and Vmn2r61.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oxotremorine M, 100 mg | sc-203656 | 100 mg | $148.00 |