Noscapine hydrochloride CAS: 912-60-7
MF: C22H23NO7•HCl
MW: 449.88
A bradykinin B and tubulin inhibitor.

Noscapine hydrochloride (CAS 912-60-7)

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Noscapine hydrochloride is rated 5.0 out of 5 by 1.
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Alternate Names: Narcotine hydrochloride
Application Noscapine hydrochloride is a bradykinin B and tubulin inhibitor
CAS 등록번호: 912-60-7
순도: ≥98%
분자량: 449.88
분자식: C22H23NO7•HCl
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

Noscapine hydrochloride is the hydrochloride form of Noscapine. Noscapine is an opioid alkaloid with several actions. Antagonist at Bradykinin B Receptor (bradykinin receptors) (pA2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues. Additionally Noscapine binds to tubulin, arrests cells in mitosis and induces apoptosis. Blocks proliferation of human leukemia and multiple myeloma cells. Furthermore, Noscapine modulates IKK activation, suppressing the NF-κB signaling pathway. Exhibits anti-inflammatory activity. Noscapine hydrochloride is an inhibitor of Tubulin.


References

1. Mourey, R.J., et al. 1992. Mol. Pharmacol. 42: 619-626.
2. Ye, K., et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 1601-1606.
3. Mahmoudian, M. and Mojaverian, M. 2001. Acta Physiol. Hung. 88: 231-237.
4. Landen, J.W., et al. 2002. Cancer Res. 62: 4109-4114.

Appearance :
Powder
Physical State :
Solid
용해도 :
Soluble in water, and 1eq. HCl (50 mM).
저장 :
Desiccate at room temperature
녹는점 :
221-223° C
굴절률 :
n20D ~1.60 (Predicted)
IC50 :
CYP2C19: IC50 = 400.3 nM (human); HepG2: IC50 >1000 nM (human); A549: EC5050 = 25 µM (human)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
Merck Index :
14: 6718
MDL Number :
MFCD00082546
EC Number :
213-014-9
SMILES :
CN1CCC2=CC3=C(C(=C2[[email protected]@H]1[[email protected]]4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3.Cl

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