Norwalk Virus Antibody (1C9): sc-53557
- Norwalk Virus Antibody (1C9) is a mouse monoclonal IgG1 κ Norwalk Virus antibody provided at 200 µg/ml
- raised against purified 8FIIa from Norwalk virus stool sample
- Norwalk Virus Antibody (1C9) is recommended for detection of the 8FIIa strain of Norwalk Virus (N-terminus of viral capsid) by IP; non cross-reactive with other caliciviruses
- Anti-Norwalk Virus Antibody (1C9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Norwalk Virus Antibody (1C9). These reagents are now offered in bundles with Norwalk Virus Antibody (1C9) (see ordering information below).
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Norwalk Virus Antibody (1C9) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Norwalk Virus protein of the 8FIIa strain Norwalk Virus origin by immunoprecipitation (IP). Norwalk Virus (1C9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Norwalk Virus, a non-cultivatable member of the genus Norovirus and the family Caliciviridae, possesses a positive strand RNA genome that encodes two key structural proteins: the major structural protein VP1 and the minor capsid protein VP2. These proteins are crucial for forming a stable capsid with icosahedral symmetry, which is essential for infectivity and stability in the environment. VP1 protein plays a significant role in attachment to host cells, as VP1 contains regions that interact with specific carbohydrates on the surface of intestinal epithelial cells. This interaction enables viral entry into the host, leading to gastrointestinal infections characterized by symptoms such as diarrhea, vomiting, and abdominal pain. Understanding the structure and function of these proteins is important for developing effective treatments and preventive measures against Norwalk Virus infections.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Norwalk Virus Antibody (1C9) References:
- X-ray crystallographic structure of the Norwalk virus capsid. | Prasad, BV., et al. 1999. Science. 286: 287-90. PMID: 10514371
- Structural requirements for the assembly of Norwalk virus-like particles. | Bertolotti-Ciarlet, A., et al. 2002. J Virol. 76: 4044-55. PMID: 11907243
- Binding of Norwalk virus-like particles to ABH histo-blood group antigens is blocked by antisera from infected human volunteers or experimentally vaccinated mice. | Harrington, PR., et al. 2002. J Virol. 76: 12335-43. PMID: 12414974
- Norwalk virus nonstructural protein p48 forms a complex with the SNARE regulator VAP-A and prevents cell surface expression of vesicular stomatitis virus G protein. | Ettayebi, K. and Hardy, ME. 2003. J Virol. 77: 11790-7. PMID: 14557663
- Histo-blood group antigen and human milk oligosaccharides: genetic polymorphism and risk of infectious diseases. | Le Pendu, J. 2004. Adv Exp Med Biol. 554: 135-43. PMID: 15384573
- Norwalk virus-specific binding to oyster digestive tissues. | Le Guyader, F., et al. 2006. Emerg Infect Dis. 12: 931-6. PMID: 16707048
- Monoclonal antibodies for detection of Norwalk virus antigen in stools. | Herrmann, JE., et al. 1995. J Clin Microbiol. 33: 2511-3. PMID: 7494063
- Three-dimensional structure of baculovirus-expressed Norwalk virus capsids. | Prasad, BV., et al. 1994. J Virol. 68: 5117-25. PMID: 8035511
- Structure of Norwalk virus. | Prasad, BV., et al. 1996. Arch Virol Suppl. 12: 237-42. PMID: 9015120
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Norwalk Virus Antibody (1C9) | sc-53557 | 200 µg/ml | $322.00 | |||
Norwalk Virus Antibody (1C9): m-IgG Fc BP-HRP Bundle | sc-526826 | 200 µg Ab; 10 µg BP | $361.00 | |||
Norwalk Virus Antibody (1C9): m-IgG1 BP-HRP Bundle | sc-532199 | 200 µg Ab; 20 µg BP | $361.00 | |||
Norwalk Virus Antibody (1C9) AC | sc-53557 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Norwalk Virus Antibody (1C9) HRP | sc-53557 HRP | 200 µg/ml | $322.00 | |||
Norwalk Virus Antibody (1C9) FITC | sc-53557 FITC | 200 µg/ml | $336.00 | |||
Norwalk Virus Antibody (1C9) PE | sc-53557 PE | 200 µg/ml | $349.00 | |||
Norwalk Virus Antibody (1C9) Alexa Fluor® 488 | sc-53557 AF488 | 200 µg/ml | $364.00 | |||
Norwalk Virus Antibody (1C9) Alexa Fluor® 546 | sc-53557 AF546 | 200 µg/ml | $364.00 | |||
Norwalk Virus Antibody (1C9) Alexa Fluor® 594 | sc-53557 AF594 | 200 µg/ml | $364.00 | |||
Norwalk Virus Antibody (1C9) Alexa Fluor® 647 | sc-53557 AF647 | 200 µg/ml | $364.00 | |||
Norwalk Virus Antibody (1C9) Alexa Fluor® 680 | sc-53557 AF680 | 200 µg/ml | $364.00 | |||
Norwalk Virus Antibody (1C9) Alexa Fluor® 790 | sc-53557 AF790 | 200 µg/ml | $364.00 |