nitrated alpha Synuclein Antibody (4H316): sc-71703

nitrated α-synuclein Antibody (4H316) is a mouse monoclonal IgG1 kappa light chain antibody developed to detect oxidized forms of α-synuclein in human, mouse, and rat samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications. nitrated α-synuclein monoclonal antibody (4H316) targets an epitope on oxidized α-synuclein, also known as NACP, enabling the identification of nitrated α-synuclein, a post-translationally modified variant implicated in the pathogenesis of neurodegenerative diseases such as Parkinson′s and Alzheimer′s. α-Synuclein is a presynaptic protein predominantly located in neuronal cell bodies and synapses, where α-synuclein plays a critical role in synaptic vesicle trafficking, neurotransmitter release, and maintaining synaptic plasticity. The nitration of α-synuclein alters normal function, promoting protein aggregation and contributing to the formation of Lewy bodies, which are characteristic of Parkinson′s disease. Additionally, α-synuclein interacts with various proteins, including synphilin-1 and Parkin, which are involved in protein degradation and cellular stress responses, highlighting α-synuclein′s central role in neuronal health and disease. Understanding the functional implications of α-synuclein nitration is essential for unraveling the molecular mechanisms underlying synaptic dysfunction and neurodegeneration. anti-nitrated α-synuclein antibody (4H316) facilitates the study of these pathological processes by enabling precise detection and analysis of modified α-synuclein in various experimental settings. Available in both unconjugated and conjugated forms, including horseradish peroxidase (HRP) and Alexa Fluor® conjugates, nitrated α-synuclein (4H316) antibody provides researchers with the necessary tools to explore the functional dynamics of α-synuclein and its role in disease progression.

The preferred alpha Synuclein antibody is alpha Synuclein Antibody (211): sc-12767.