nitrated alpha/beta Synuclein Antibody (4H317): sc-71702

nitrated α/β-synuclein Antibody (4H317) is a mouse monoclonal IgG1 kappa light chain antibody developed to detect nitrated forms of α-synuclein and β-synuclein proteins in human samples. nitrated α/β-synuclein monoclonal antibody (4H317) is raised against recombinant human α-synuclein that has been nitrated in vitro, making it suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). α-Synuclein, also known as NACP, and β-synuclein, designated as PNP-14, are presynaptic proteins primarily located in the synaptic terminals of neurons within the brain, where they play vital roles in synaptic vesicle trafficking and neurotransmitter release. The precise localization of these synucleins at the synapse is essential for maintaining effective neuronal communication and plasticity. Nitration, a significant post-translational modification, affects the subcellular distribution and function of synucleins, promoting their aggregation and contributing to the pathological characteristics of neurodegenerative diseases such as Parkinson′s and Alzheimer′s disease. By targeting nitrated synucleins, anti-nitrated α/β-synuclein antibody (4H317) enables researchers to study the altered cellular localization and aggregation patterns of these proteins, providing critical insights into disease mechanisms. Additionally, the presence of nitrated synucleins at the synapse can disrupt synaptic integrity and neuronal health, underscoring the importance of this modification in disease progression. nitrated α/β-synuclein (4H317) antibody is available in both unconjugated form and various conjugated forms, including horseradish peroxidase (HRP) and Alexa Fluor® conjugates, offering versatility for different experimental needs.

The preferred alpha Synuclein antibody is alpha Synuclein Antibody (211): sc-12767.