Myosin-neonatal Antibody (N1.551): sc-53097

Myosin-neonatal Antibody (N1.551) is a mouse monoclonal IgM antibody that detects Myosin-neonatal protein of mouse, rat, human, and rabbit origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Myosin-neonatal antibody (N1.551) is available as the non-conjugated form. Myosin is a critical motor protein that plays a vital role in muscle contraction and various cellular movements, including cytokinesis and phagocytosis. Myosin consists of a hexamer formed by four light chains and two heavy chains, with each heavy chain being approximately 2000 amino acids long. The heavy chains contain distinct N-terminal and C-terminal domains that adopt a coiled-coil configuration, allowing Myosin to form bipolar filaments that interact with actin filaments. This interaction generates the force required for muscle contraction, coupled with ATP hydrolysis. In vertebrates, multiple classes of Myosins exist, including both muscle and non-muscle types, with neonatal Myosin specifically characterized by fast-type light chains. Understanding Myosin′s structure and function helps elucidate muscle development mechanisms and muscle-related disease pathophysiology.

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Myosin-neonatal Antibody (N1.551) References:

1. A myosin family tree.  |  Hodge, T. and Cope, MJ. 2000. J Cell Sci. 113 Pt 19: 3353-4. PMID: 10984423
2. Adult extracardiac rhabdomyoma: light and immunohistochemical studies of two cases in the parapharyngeal space.  |  Bjørndal Sørensen, K., et al. 2006. Head Neck. 28: 275-9. PMID: 16419079
3. Contractile protein isozymes in muscle development: identification of an embryonic form of myosin heavy chain.  |  Whalen, RG., et al. 1979. Proc Natl Acad Sci U S A. 76: 5197-201. PMID: 291935
4. Myosin structure and function in cell motility.  |  Warrick, HM. and Spudich, JA. 1987. Annu Rev Cell Biol. 3: 379-421. PMID: 3318880
5. The myosin alkali light chain proteins and their genes.  |  Barton, PJ. and Buckingham, ME. 1985. Biochem J. 231: 249-61. PMID: 3904738
6. ATPase activity of myosin correlated with speed of muscle shortening.  |  Bárány, M. 1967. J Gen Physiol. 50: Suppl:197-218. PMID: 4227924
7. Myosin subunit composition in human developing muscle.  |  Biral, D., et al. 1984. Biochem J. 224: 923-31. PMID: 6395865
8. Myosin types in human skeletal muscle fibers.  |  Billeter, R., et al. 1980. Histochemistry. 65: 249-59. PMID: 6445347
9. Three slow myosin heavy chains sequentially expressed in developing mammalian skeletal muscle.  |  Hughes, SM., et al. 1993. Dev Biol. 158: 183-99. PMID: 7687223

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Myosin-neonatal Antibody (N1.551) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-Myosin-neonatal Antibody (N1.551) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Myosin-neonatal Antibody (N1.551) Specifications

Alternate Product Name: Myosin-neonatal

Product Clone Name: N1.551

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: neonatal Myosins

Epitope Species: human

Product Reactivity/Detection: neonatal myosin

Species Reactivity/Detection: mouse, rat, human, rabbit

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for Myosin-neonatal Antibody (N1.551): N/A