MT-MMP-6 Antibody (MM0029-2B5): sc-101453

MT-MMP-6 Antibody (MM0029-2B5) is a mouse monoclonal IgG1 antibody that detects MT-MMP-6 protein of human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry. Anti-MT-MMP-6 antibody (MM0029-2B5) is available as a non-conjugated format. The matrix metalloproteinases (MMPs) are a crucial family of peptidase enzymes responsible for degrading extracellular matrix components, including collagen, gelatin, fibronectin, laminin, and proteoglycans, which are vital for tissue remodeling and repair. MT-MMP-6, also known as MMP-25, MT6-MMP, or leukolysin, is the second glycosylphosphatidylinositol (GPI)-anchored proteinase in the MMP family, allowing localization to the cell membrane where MT-MMP-6 effectively interacts with other matrix components. This localization enables MT-MMP-6 to activate other MMPs, cleave type IV collagen, fibronectin, fibrin, and gelatin, although MT-MMP-6 does not cleave laminin-1 or activate progelatinase B. Members of the proprotein convertase family mediate MT-MMP-6 activation, indicating a complex regulatory mechanism involving a proprotein convertase/MT-MMP/MMP cascade crucial for extracellular matrix turnover. MT-MMP-6 expression occurs in various tissues, including leukocytes, lung, and spleen, highlighting MT-MMP-6′s potential role in immune responses and tissue homeostasis.

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MT-MMP-6 Antibody (MM0029-2B5) References:

1. Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage.  |  Pei, D. 1999. Cell Res. 9: 291-303. PMID: 10628838
2. Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors.  |  Velasco, G., et al. 2000. Cancer Res. 60: 877-82. PMID: 10706098
3. Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP.  |  Kojima, S., et al. 2000. FEBS Lett. 480: 142-6. PMID: 11034316
4. Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25).  |  English, WR., et al. 2001. FEBS Lett. 491: 137-42. PMID: 11226436
5. Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bond.  |  Nie, J. and Pei, D. 2003. Cancer Res. 63: 6758-62. PMID: 14583471
6. MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties.  |  Sun, Q., et al. 2007. J Biol Chem. 282: 21998-2010. PMID: 17513868
7. MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer.  |  Sohail, A., et al. 2008. Cancer Metastasis Rev. 27: 289-302. PMID: 18286233

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MT-MMP-6 Antibody (MM0029-2B5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-MT-MMP-6 Antibody (MM0029-2B5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MT-MMP-6 Antibody (MM0029-2B5) Specifications

Alternate Product Name: MT-MMP-6

Product Clone Name: MM0029-2B5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: MT-MMP-6

Epitope Species: human

Product Reactivity/Detection: MT-MMP-6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for MT-MMP-6 Antibody (MM0029-2B5): N/A