Molecular structure of MK-2461, CAS Number: 917879-39-1
MK-2461 (CAS 917879-39-1)
Alternate Names:
5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one
Application:
MK-2461 is a multi-targeted inhibitor
CAS Number:
917879-39-1
Purity:
≥99%
Molecular Weight:
495.55
Molecular Formula:
C24H25N5O5S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
MK-2461 is a potent inhibitor of Met, Ron, Flt1, Flt 3, PDGFRβ, and Mer with IC50 of 2.5 nM, 7 nM, 10 nM, 22 nM, 22 nM and 24 nM, respectively.
MK-2461 (CAS 917879-39-1) References
- Homogeneous proximity tyrosine kinase assays: scintillation proximity assay versus homogeneous time-resolved fluorescence. | Park, YW., et al. 1999. Anal Biochem. 269: 94-104. PMID: 10094779
- MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. | Pan, BS., et al. 2010. Cancer Res. 70: 1524-33. PMID: 20145145
- Genetic alterations of FGF receptors: an emerging field in clinical cancer diagnostics and therapeutics. | Katoh, M. 2010. Expert Rev Anticancer Ther. 10: 1375-9. PMID: 20836672
- Structural basis for selective small molecule kinase inhibition of activated c-Met. | Rickert, KW., et al. 2011. J Biol Chem. 286: 11218-25. PMID: 21247903
- Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer. | Katz, JD., et al. 2011. J Med Chem. 54: 4092-108. PMID: 21608528
- Design and synthesis of novel substituted naphthyridines as potential c-Met kinase inhibitors based on MK-2461. | Wu, JF., et al. 2015. Bioorg Med Chem Lett. 25: 3251-5. PMID: 26077488
- Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. | Klaeger, S., et al. 2016. ACS Chem Biol. 11: 1245-54. PMID: 26863403
- VEGF-A regulates sFlt-1 production in trophoblasts through both Flt-1 and KDR receptors. | Xiao, Z., et al. 2018. Mol Cell Biochem. 449: 1-8. PMID: 29497919
- Targeting the C-MET/HGF Signaling Pathway in Pancreatic Ductal Adenocarcinoma. | Ghanaatgar-Kasbi, S., et al. 2018. Curr Pharm Des. 24: 4619-4625. PMID: 30636579
- Identification of INHBA as a potential biomarker for gastric cancer through a comprehensive analysis. | Liu, F., et al. 2023. Sci Rep. 13: 12494. PMID: 37528145
Inhibitor of:
Met.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MK-2461, 5 mg | sc-364538 | 5 mg | $540.00 | |||
MK-2461, 10 mg | sc-364538A | 10 mg | $825.00 |