Mastoparan CAS: 72093-21-1
MF: C70H131N19O15
MW: 1478.93
A G-protein activator.

Mastoparan (CAS 72093-21-1)

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Application A G-protein activator
CAS 등록번호: 72093-21-1
분자량: 1478.93
분자식: C70H131N19O15
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Mastoparan (Vespula lewisii) has been shown to cause an increase in the production of Arachidonic Acid (sc-200770) catalyzed by PLA2 from porcine pancreas and bee venom. This compound also displays toxicity by regulating G proteins via mimicking of G-protein-coupled receptors. Additionally, Mastoparan has been reported as a stimulator of insulin release by pancreatic islets, which acts through GTP-binding proteins and PLA2. In other experiments, this agent has demonstrated the ability to cause exocytosis of rat peritoneal mast cells and also stimulate the accumulation of inositol phosphates in hepatocytes. Additionally, Mastoparan has been noted to act as a mitogen in Swiss 3T3 cells and stimulate pertussis toxin-sensitive Arachidonate release without phosphoinositide breakdown. Mastoparan (Vespula lewisii) is an inhibitor of CaM. Mastoparan (Vespula lewisii) is an activator of Heterotrimeric G Protein and PLA2.


References

1. Argiolas, A. and Pisano, J.J. 1983. J. Biol. Chem. 258: 13697-13702. PMID: 6643447
2. Higashijima, T., et al. 1988. J. Biol. Chem. 263: 6491-6494. PMID: 3129426
3. Yokokawa, N., et al. 1989. Biochem. Biophys. Res. Commun. 158: 712-716. PMID: 2493246
4. Mousli, M., et al. 1989. J. Pharmacol. Exp. Ther. 250: 329-335. PMID: 2473189
5. Higashijima, T., et al. 1990. J. Biol. Chem. 265: 14176-14186. PMID: 2117607
6. Gil, J., et al. 1991. J. Cell Biol. 113: 943-950. PMID: 1709171

Physical State :
Solid
에서 유래된 :
Synthetic. Originally isolated from wasp venom (Vespula lewisii)
용해도 :
Soluble in water (2.6 mg/ml), and 100% ethanol.
저장 :
Store at -20° C
굴절률 :
n20D 1.53
IC50 :
Na+,K+-ATPase: IC50 = 7.5 µM
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
5464497
MDL Number :
MFCD00076865
Beilstein Registry :
5491949
SMILES :
CC[[email protected]](C)[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)N)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](CCCCN)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CCCCN)C(=O)N[[email protected]@H](CCCCN)C(=O)N[[email protected]@H](C(C)CC)C(=O)N[[email protected]@H](CC(C)C)C(=O)N)N

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