LHX5 Antibody (KP-02): sc-130469

LHX5 Antibody (KP-02) is a mouse monoclonal IgG2a kappa light chain antibody that detects LHX5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LHX5 (KP-02) antibody is available as the non-conjugated form. LHX5 protein plays a critical role in the development of the central nervous system, particularly in the hippocampus, where LHX5 is involved in the regulation of precursor cell proliferation and neuronal differentiation. This regulation is essential for proper hippocampal development, which is crucial for cognitive functions such as learning and memory. LHX5 protein is characterized by a LIM domain, a unique cysteine-rich zinc-binding domain that facilitates protein-protein interactions, allowing LHX5 to influence the expression of other genes involved in neuronal development. Human LHX5 gene is located on chromosome 12q23-q24 and encodes a 402 amino acid protein, which is part of a larger family of LIM-type homeodomain factors that guide motor axons and ensure the fidelity of axonal trajectories during development. By understanding LHX5 function and importance, researchers can gain insights into the molecular mechanisms underlying neurodevelopmental processes and potential implications in neurological disorders.

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LHX5 Antibody (KP-02) References:

1. Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5.  |  Zhao, Y., et al. 1999. Science. 284: 1155-8. PMID: 10325223
2. The LIM homeodomain protein dLim1 defines a subclass of neurons within the embryonic ventral nerve cord of Drosophila.  |  Lilly, B., et al. 1999. Mech Dev. 88: 195-205. PMID: 10534618
3. Requirement of LIM domains for LIM1 function in mouse head development.  |  Cheah, SS., et al. 2000. Genesis. 27: 12-21. PMID: 10862151
4. Genetic and epigenetic mechanisms contribute to motor neuron pathfinding.  |  Sharma, K., et al. 2000. Nature. 406: 515-9. PMID: 10952312

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LHX5 Antibody (KP-02) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-LHX5 Antibody (KP-02) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LHX5 Antibody (KP-02) Specifications

Alternate Product Name: LHX5

Product Clone Name: KP-02

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 136-236

Epitope Target: LHX5

Epitope Species: human

Product Reactivity/Detection: LHX5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for LHX5 Antibody (KP-02): N/A