Leupeptin hydrochloride (CAS 24125-16-4)
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Leupeptin hydrochloride is widely recognized for its role in biochemical research, particularly due to its properties as an inhibitor of various proteases. This compound is especially valuable in studies involving the breakdown of proteins and peptides, as it helps in controlling the activity of proteases that can degrade proteins of interest, thereby preserving the integrity of samples during analysis. Leupeptin hydrochloride plays a role in experiments that require the inhibition of proteolytic activity to prevent the degradation of proteins, which is essential for accurate protein quantification, identification, and analysis. This makes it an indispensable reagent in protocols for protein extraction, purification, and characterization Leupeptin hydrochloride′s properties also make it an interesting compound for potential applications in the preservation of biological specimens. By inhibiting proteases, it can help in maintaining the structural integrity of biological tissues and cells, which is for various analytical procedures in histology and cytology.
Leupeptin hydrochloride (CAS 24125-16-4) References
- Inhibition of calpains, by treatment with leupeptin, improves motoneuron survival and muscle function in models of motoneuron degeneration. | Kieran, D. and Greensmith, L. 2004. Neuroscience. 125: 427-39. PMID: 15062985
- Scrapie protein degradation by cysteine proteases in CD11c+ dendritic cells and GT1-1 neuronal cells. | Luhr, KM., et al. 2004. J Virol. 78: 4776-82. PMID: 15078959
- Mechanical ventilation with moderate tidal volumes synergistically increases lung cytokine response to systemic endotoxin. | Altemeier, WA., et al. 2004. Am J Physiol Lung Cell Mol Physiol. 287: L533-42. PMID: 15145786
- Proteinase-activated receptor2 agonists upregulate granulocyte colony-stimulating factor, IL-8, and VCAM-1 expression in human bronchial fibroblasts. | Ramachandran, R., et al. 2006. Am J Respir Cell Mol Biol. 35: 133-41. PMID: 16498082
- Leupeptin, a calpain inhibitor, protects inner ear hair cells from aminoglycoside ototoxicity. | Momiyama, J., et al. 2006. Tohoku J Exp Med. 209: 89-97. PMID: 16707850
- Probing the structure and activity of trypsin with amidination. | Liu, X., et al. 2007. Anal Biochem. 367: 13-9. PMID: 17560535
- Proteasome inhibition suppresses Schwann cell dedifferentiation in vitro and in vivo. | Lee, HK., et al. 2009. Glia. 57: 1825-34. PMID: 19455715
- Δ(9) desaturase protein expression and fatty acid composition of longissimus dorsi muscle in lambs fed green herbage or concentrate with or without added tannins. | Vasta, V., et al. 2009. Meat Sci. 82: 357-64. PMID: 20416712
- Matrix remodeling as stem cell recruitment event: a novel in vitro model for homing of human bone marrow stromal cells to the site of injury shows crucial role of extracellular collagen matrix. | Mauney, J., et al. 2010. Matrix Biol. 29: 657-63. PMID: 20828613
- Leupeptin preserves cardiac nitric oxide synthase 3 during reperfusion following long-term cardioplegia. | Muscari, C., et al. 2010. J Surg Res. 164: e27-35. PMID: 20828747
- Novel cathepsin L-like protease from dermestid beetle Dermestes frischii maggot. | Papisova, AI., et al. 2011. Biochimie. 93: 141-8. PMID: 20868724
- Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen. | Wu, LC., et al. 2011. J Biol Chem. 286: 24916-30. PMID: 21515882
- Severe reaction to radiotherapy for breast cancer as the presenting feature of ataxia telangiectasia. | Byrd, PJ., et al. 2012. Br J Cancer. 106: 262-8. PMID: 22146522
- A novel function for p21Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGFβ-mediated breast cancer cell migration and invasion. | Dai, M., et al. 2012. Breast Cancer Res. 14: R127. PMID: 22995475
- Liquid chromatographic nanofractionation with parallel mass spectrometric detection for the screening of plasmin inhibitors and (metallo)proteinases in snake venoms. | Zietek, BM., et al. 2018. Anal Bioanal Chem. 410: 5751-5763. PMID: 30090989
- Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) With Skeletal Muscle Ryanodine Receptor Type 1. | Truong, KM., et al. 2019. Toxicol Sci. 170: 509-524. PMID: 31127943
- Leupeptins, new protease inhibitors from Actinomycetes. | Aoyagi, T., et al. 1969. J Antibiot (Tokyo). 22: 283-6. PMID: 5810993
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Leupeptin hydrochloride, 5 mg | sc-215242 | 5 mg | $80.00 | |||
Leupeptin hydrochloride, 25 mg | sc-215242A | 25 mg | $253.00 |