LCS 1 (CAS 41931-13-9)
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LCS 1, chemically known as 1,4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, is a compound with research applications that extend into the area of cancer biology, particularly in the study of lung cancer mechanisms. As an inhibitor of superoxide dismutase 1 (SOD1), LCS 1 serves as a tool for probing the role of oxidative stress and reactive oxygen species in the pathophysiology of lung cancer. Its ability to modulate SOD1 activity allows researchers to investigate the enzyme′s contribution to cellular defense mechanisms against oxidative damage and its potential involvement in cancer cell proliferation and survival. The compound′s role in cancer research is also associated with understanding how modulating antioxidant enzymes might influence tumor growth and metastasis.
LCS 1 (CAS 41931-13-9) References
- Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. | Somwar, R., et al. 2011. Proc Natl Acad Sci U S A. 108: 16375-80. PMID: 21930909
- Cytotoxic Activity of LCS-1 is not Only due to Inhibition of SOD1. | Steverding, D. and Barcelos, Y. 2020. Drug Res (Stuttg). 70: 57-60. PMID: 31509855
- LCS-1 inhibition of superoxide dismutase 1 induces ROS-dependent death of glioma cells and degradates PARP and BRCA1. | Ling, M., et al. 2022. Front Oncol. 12: 937444. PMID: 35978820
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LCS 1, 5 mg | sc-394311 | 5 mg | $104.00 | |||
LCS 1, 25 mg | sc-394311A | 25 mg | $424.00 |